The role of ErbB3 and its binding partners in breast cancer progression and resistance to hormone and tyrosine kinase directed therapies.

Journal of Mammary Gland Biology and Neoplasia
A W Hamburger

Abstract

An increasingly important role for the ErbB3 receptor in the genesis and progression of breast cancer is emerging. ErbB3 is frequently overexpressed in breast cancer and coexpression of ErbB2/3 is a poor prognostic indicator. ErbB3 has also been implicated in the development of resistance to antiestrogens such as tamoxifen and ErbB tyrosine kinase inhibitors such as gefitinib. Persistent activation of the AKT pathway has been postulated to contribute to ErbB3-mediated resistance to these therapies. This activation may be due in part to the inappropriate production of the ErbB3 ligand heregulin. ErbB3 binding proteins, which negatively regulate ErbB3 protein levels and the ability of ErbB3 to transmit proliferative signals, also contribute to breast cancer progression and treatment resistance. These proteins include the intracellular RING finger E3 ubiquitin ligase Nrdp1 and the leucine-rich protein LRIG-1 that mediate receptor degradation. Ebp1, another ErbB3 binding protein, suppresses HRG driven breast cancer cell growth and contributes to tamoxifen sensitivity. These studies point to the importance of the evaluation of protein levels and functional activity of ErbB3 and its binding proteins in breast cancer prognosis and pre...Continue Reading

References

Dec 1, 1992·British Journal of Cancer·N R LemoineH C Hurst
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M H KrausS A Aaronson
Jun 1, 1994·Molecular and Cellular Biology·S P SoltoffL C Cantley
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G GaspariniP Bevilacqua
Jan 1, 1993·Breast Cancer Research and Treatment·C C BenzC K Osborne
Jul 25, 1998·The Biochemical Journal·N J HellyerJ G Koland
Nov 21, 1998·British Journal of Cancer·R NaiduM K Kutty
Mar 27, 2001·Journal of Cellular Physiology·X XiaA W Hamburger
Apr 28, 2001·Molecular and Cellular Endocrinology·T J Lessor, A W Hamburger
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y Yarden
Nov 16, 2001·Biochemical and Biophysical Research Communications·X XiaA W Hamburger
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·A John DiamontiKermit L Carraway
Jun 5, 2002·The Journal of Cell Biology·Martin OffterdingerThomas W Grunt
Nov 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Bo Qiu, Alfred L Goldberg
Mar 22, 2003·Experimental Cell Research·Thomas HolbroNancy E Hynes
Jul 8, 2003·The Journal of Pathology·Caroline J WittonJohn M S Bartlett
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas HolbroNancy E Hynes
Jul 17, 2003·International Journal of Cancer. Journal International Du Cancer·Ivan BiècheRosette Lidereau
Jul 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Chi-Hong B ChenRalf Landgraf
Oct 31, 2003·Cancer Cell·Ji LuoLewis C Cantley
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·Henning T MouridsenIan E Smith
Jun 17, 2004·Journal of the National Cancer Institute·Jiang ShouRachel Schiff
Aug 18, 2004·Molecular and Cellular Biology·Xiuli WuKermit L Carraway
Sep 4, 2004·The Journal of Biological Chemistry·Melanie B LaederichColleen Sweeney
Sep 21, 2004·Breast Cancer Research and Treatment·Nicola J JordanRobert I Nicholson
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda A deGraffenriedManuel Hidalgo
Feb 11, 2005·International Journal of Cancer. Journal International Du Cancer·Edward Htun van der HorstAxel Ullrich
Mar 25, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicola L P BarnesNigel J Bundred
May 3, 2005·Nature Reviews. Cancer·Nancy E Hynes, Heidi A Lane
Jul 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sian ToveyJohn M S Bartlett
Aug 23, 2005·Endocrine-related Cancer·A AgrawalJ F R Robertson
Sep 20, 2005·Breast Cancer Research : BCR·Ingrid LjuslinderRoger Henriksson
Oct 29, 2005·Nucleic Acids Research·Yuexing ZhangAnne W Hamburger
Apr 25, 2006·Biochemical and Biophysical Research Communications·Massimo SquatritoGiulio F Draetta
May 18, 2006·Journal of the National Cancer Institute·Caroline HolmGöran Landberg

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Citations

Feb 4, 2010·Archives of Virology·M GopinathM S Shaila
May 6, 2008·Journal of Mammary Gland Biology and Neoplasia·Maria SundvallKlaus Elenius
May 6, 2008·Journal of Mammary Gland Biology and Neoplasia·David F Stern
Mar 23, 2012·Carcinogenesis·Malgorzata Magdalena SakInger Helene Madshus
May 18, 2011·Molecular and Cellular Biology·William H D FryKermit L Carraway
Dec 22, 2009·Future Oncology·Maija Hollmén, Klaus Elenius
May 14, 2014·Trends in Cell Biology·Veronika ReitererHesso Farhan
Nov 26, 2009·Journal of Cancer Research and Clinical Oncology·Xu ZhouYoucheng Yu
Mar 15, 2015·Journal of Molecular Biology·Yibin XuAntony W Burgess
Sep 28, 2010·Seminars in Cell & Developmental Biology·Kermit L Carraway
Oct 16, 2016·The Journal of Membrane Biology·Ignat PrintsevKermit L Carraway
Nov 16, 2018·Journal of Biochemical and Molecular Toxicology·Gang GuoZheng Chen
Feb 20, 2018·Molecular Cancer·Qian LiuKongming Wu
Oct 20, 2015·Scientific Reports·Maria RosestedtStefan Ståhl
May 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Clifford A TolemanMichael Boyce
Feb 23, 2020·Virchows Archiv : an International Journal of Pathology·Jing LiuYun Niu
Oct 23, 2020·International Journal of Molecular Sciences·Adriana PapadimitropoulouRuth Lupu

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