The role of erythrocytes in the deperoxidative processes in people on hemodialysis

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
S BiasioliD Giavarina

Abstract

The defenses against the production of free radicals and reactive oxygen species (ROS) are to be found in plasma (ascorbate, urate, alpha tocopherol) and in erythrocytes (superoxide dismutase or SOD; catalase or CAT; glutathione peroxidase or GPx). In chronic renal failure, an increased lipid peroxidation and a reduced antioxidant activity seem to be present, but previous reports are conflicting. To clarify the peroxidative status and the defense mechanisms taking place in patients on dialysis, in 30 patients on dialysis (15 men, 15 women) and in 20 control subjects (10 men, 10 women), the following parameters were measured: plasma 4-hydroxinonenal (4-HNE) and erythrocyte reduced glutathione (GSH), SOD, GPx, and glucose-6-phosphate dehydrogenase (G-6-PD). Patients on dialysis, in comparison with control subjects, had 1) increased levels of 4-HNE (p < 0.001); 2) a significant increase in erythrocyte-GSH (p < 0.05); and 3) significant decreases in erythrocyte-SOD (p < 0.001), erythrocyte-G-6-PD (p < 0.005), and the erythrocyte-SOD/GPx ratio (p < 0.001). The dialysis procedure induced a certain reduction in plasma 4-HNE, an increase in erythrocyte-SOD activity, and an important consumption of erythrocyte-GSH, while the erythrocyte...Continue Reading

Citations

Oct 16, 2004·Digestive Diseases and Sciences·Ioannis E KoutroubakisElias A Kouroumalis
Jul 3, 2003·BMC Nephrology·Niki MalliarakiElias Castanas
Oct 4, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S BiasioliD Borin
Sep 29, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S BiasioliL Targa
Oct 30, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A KlemmG Stein

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