Abstract
Chronic prostatitis (CP) is a common disease within the field of urology, and it is difficult to treat. Prostatitis mainly occurs in young men and presents with various clinical symptoms, manifested as urinary frequency, urinary urgency, urinary pain, prolonged urination, dysuria and other urinary abnormalities. There are various forms of the syndrome that can cause discomfort or pain in the perineum, the lower abdomen, the penis, the scrotum and the lumbosacral area. To investigate CP in more detail, animal models are necessary to determine the etiology of prostatitis and develop new, specific drug therapies. In the present study, Sprague Dawley rats that were induced to develop a model of chronic and non‑bacterial prostatitis drank ethanol or water to determine the effects of ethanol on prostatitis. Total antioxidant capacity, the concentration of inflammatory factors, such as tumor necrosis factor‑α and interleukin‑1β, and the expression changes of α1‑adrenoreceptor were measured. The susceptibility of ethanol‑drinking rats to CP was confirmed and some simple mechanism of this susceptibility was investigated to further guide the diagnosis and treatment of patients with prostatitis.
References
Jul 1, 1994·The Journal of Urology·D W KeetchT L Ratliff
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 18, 2008·The Journal of Urology·Nicolas B DelongchampsGabriel P Haas
Jun 28, 2008·The Journal of Pharmacology and Experimental Therapeutics·Emrah YatkinRisto Santti
Jul 29, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Bozena Zdrodowska-StefanowZofia Galewska
Feb 22, 2011·The Journal of Urology·Rodney U AndersonElaine K Orenberg
Mar 21, 2013·Journal of Hepatology·Jürgen RehmKevin D Shield
Sep 10, 2014·Nutrients·Joo Ho LeeSang-Woon Choi
Dec 11, 2014·Indian Journal of Cancer·V ThakurP P Singh
Jan 2, 2015·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Adrijana KrsmanovicMary F McNaughton-Collins
May 6, 2015·Prostate Cancer and Prostatic Diseases·S SahinM Cek
May 24, 2015·Journal of Biomedical Nanotechnology·Chunhui LaiXiaoling Lu
Jun 25, 2015·NeuroImage. Clinical·Jason J KutchEmeran A Mayer
Jul 15, 2015·Current Medical Research and Opinion·Dong CuiYueFeng Du
Jul 29, 2015·Scientific Reports·Kazem ZibaraMarwan El-Sabban
Sep 1, 2015·Asian Pacific Journal of Tropical Medicine·Dong-Fang ZhangRan Li
Sep 4, 2015·The World Journal of Men's Health·Gilho Lee
Sep 10, 2015·BJU International·Antonella Giannantoni, Silvia Proietti
Sep 29, 2015·European Urology·Giuseppe MagistroJ Curtis Nickel
Dec 9, 2015·BMC Urology·Hiromichi IwamuraChikara Ohyama
Feb 4, 2016·Andrologia·Y-J LiuG T Liu
Apr 28, 2016·PloS One·Yadong ZhangChunhua Deng