The role of ETS transcription factors in transcription and development of mouse preimplantation embryos

Biochemical and Biophysical Research Communications
Shun-ichiro KageyamaFugaku Aoki

Abstract

Embryonic transcription is a crucial process for the creation of new life. To clarify the mechanism of embryonic transcription, we investigated the expression and function of the erythroblast transformation specific (ETS) domain containing transcription factors (TFs) during preimplantation development in mice. The expression levels of several ETS TFs, i.e., etsrp71, elf3, and spic, increased after fertilization and remained at a high level until the blastocyst stage. To clarify the function of these TFs, we performed gene suppression using RNA interference, which revealed that they were involved in regulating development to the blastocyst stage. Furthermore, we found that suppression of ETS TFs affected the transcription of eIF-1A and oct3/4 genes whose expression is regulated by TATA-less promoters in the embryos. These results suggest that ETS TFs function in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.

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Nov 19, 2005·The Journal of Reproduction and Development·Shun-ichiro KageyamaFugaku Aoki

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Citations

Nov 7, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Christian VigneaultMarc-André Sirard
Jun 28, 2014·Biochemical and Biophysical Research Communications·Sung-Won ParkJae-Hwan Kim
Jul 26, 2016·Frontiers in Cell and Developmental Biology·Chan Mi LeeJim Hu
Oct 13, 2017·Biology of Reproduction·James L ChitwoodPablo J Ross
Jun 29, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jordan R OliverJim Hu
Dec 14, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jordan R OliverJim Hu
Mar 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen K H LiRodney P DeKoter
Sep 2, 2017·Cardiovascular Research·Naoko Koyano-Nakagawa, Daniel J Garry
Mar 7, 2021·Journal of Personalized Medicine·Melis Savasan SogutIsil Aksan Kurnaz

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