The Role of Eugenol in the Prevention of Acute Pancreatitis-Induced Acute Kidney Injury: Experimental Study

HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
Charalampos MarkakisConstantinos Simopoulos

Abstract

Aim. Acute pancreatitis is an inflammatory intra-abdominal disease, which takes a severe form in 15-20% of patients and can result in high mortality especially when complicated by acute renal failure. The aim of this study is to assess the possible reduction in the extent of acute kidney injury after administration of eugenol in an experimental model of acute pancreatitis. Materials and Methods. 106 male Wistar rats weighing 220-350 g were divided into 3 groups: (1) Sham, with sham surgery; (2) Control, with induction of acute pancreatitis, through ligation of the biliopancreatic duct; and (3) Eugenol, with induction of acute pancreatitis and eugenol administration at a dose of 15 mg/kg. Serum urea and creatinine, histopathological changes, TNF-α, IL-6, and MPO activity in the kidneys were evaluated at predetermined time intervals. Results. The group that was administered eugenol showed milder histopathological changes than the Control group, TNF-α activity was milder in the Eugenol group, and there was no difference in activity for MPO and IL-6. Serum urea and creatinine levels were lower in the Eugenol group than in the Control group. Conclusions. Eugenol administration was protective for the kidneys in an experimental model ...Continue Reading

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Citations

Mar 16, 2017·Phytotherapy Research : PTR·Pratibha AnchiChandraiah Godugu
Jan 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Renner Philipe Rodrigues CarvalhoMariana Machado-Neves

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Methods Mentioned

BETA
biopsy

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SPSS Package for the Social Sciences

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