The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases

Mediators of Inflammation
Fabio MorandiFabio Malavasi

Abstract

Adenosine (ADO) is an immunosuppressive molecule, which suppresses the immune responses by interacting with specific receptors expressed by immune effector cells. ADO is produced from ATP through the enzymatic activities of CD39 and CD73. Alternatively, ADO can be generated starting from NAD+, which is metabolized by the concerted action of CD38, CD203a/PC-1, and CD73. The role of ADO in immunity has been characterized in the last years in physiology and in pathological settings. This review examines a panel of reports focused on the functions of ADO in the context of human autoimmune/inflammatory diseases and the selected animal models. The final aim is to consider the role of adenosinergic ectoenzymes and ADO receptors as novel therapeutic targets for selected diseases.

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Citations

Mar 1, 2019·International Journal of Molecular Sciences·Valeria GasperiMaria Valeria Catani
Sep 26, 2019·Frontiers in Immunology·Jian Hang LamTony Kiat Hon Lim
Jul 25, 2019·Current Pharmaceutical Design·Sumit JamwalAmal Al-Aboudi
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Apr 1, 2021·Physiological Reviews·Alberto L HorensteinFabio Malavasi
Oct 1, 2019·Journal of Autoimmunity·Chuan HuangZhe-Xiong Lian
Oct 16, 2021·Frontiers in Pharmacology·Tingyu PanHailang He

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