The role of extracellular inducer of matrix metalloproteinases in premature rupture of membranes

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Gennady T SukhikhNataliya V Dolgushina

Abstract

To investigate the role of matrix metalloproteinases (MMP-2, MMP-9) and their inducer (CD147) in premature rupture of membranes (PROM) at term labor. In a cross-sectional study, 24 women aged 19-39, with 37-40-week pregnancy, and no clinical and histological signs of chorioamnionitis, were divided into two groups with and without PROM. The histological and immunohistochemical study of the fetal membranes was performed with polyclonal rabbit antibodies to MMP-2/MMP-9 and monoclonal rabbit antibodies to CD147. The analysis of MMP revealed the increase of MMP-9 expression in the amniotic epithelium during premature membrane rupture both in rupture area, and beyond it, and increased MMR-2 expression in the mesodermal cells. We also found high level of CD147 in the amniotic epithelium in PROM group. The above-mentioned changes were found in all areas of fetal membranes, regardless of the rupture localization. The study results demonstrate the increased expression of MMR-2 and MMR-9, which regulate the catabolism of fetal membrane extracellular matrix proteins, in amniotic membranes of women with PROM at term labor. The increased expression of CD147 may be one of the mechanisms triggering PROM in the absence of infection.

References

Nov 20, 2002·American Journal of Obstetrics and Gynecology·Roberto RomeroStanley Berry
May 27, 2003·American Journal of Reproductive Immunology : AJRI·Stephen J FortunatoRamkumar Menon
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Wei LiJohn R G Challis
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Amir WeissEliezer Shalev
Apr 3, 2007·Obstetrics and Gynecology·UNKNOWN ACOG Committee on Practice Bulletins-Obstetrics
Jun 15, 2007·Acta histochemica·Ayşe Yasemin Demir-WeustenBerthold Huppertz
Mar 4, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gian Carlo Di RenzoYves Ville

❮ Previous
Next ❯

Citations

Apr 24, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Ramkumar Menon, Stephen J Fortunato
Mar 23, 2019·International Journal of Molecular Sciences·Stephan DreschersThorsten W Orlikowsky
Apr 20, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ge ZuoYan Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Related Papers

Revista latinoamericana de perinatología : órgano oficial de la Federación Latinoamericana de Asociaciones de Medicina [Perinatal] (F.L.A.M.P.)
R Lopez Garcia
© 2022 Meta ULC. All rights reserved