PMID: 11321233Apr 26, 2001Paper

The role of Fas-FasL in CD8+ T-cell-mediated insulin-dependent diabetes mellitus (IDDM)

Journal of Clinical Immunology
H T Kreuwel, L A Sherman

Abstract

In the past few years a number of studies have evaluated the contributions of different cytolytic pathways in the autoimmune destruction of pancreatic beta cells, which results in insulin-dependent (type I) diabetes mellitus. Conflicting results continue to emerge regarding the role of Fas-mediated apoptosis in beta-cell destruction. This is likely to reflect differences inherent to the model systems under investigation, as well as the pleiotropic nature of the genes that are involved in cytotoxicity. Despite these complications, it may be possible to reconcile some of these apparently conflicting results by considering that T-cell-mediated cytotoxicity can occur simultaneously by several mechanisms and that variables such as the cytokine milieu and the strength of the signal to the T cell received through the T-cell receptor complex may alter the relative contribution of each cytolytic pathway to beta-cell destruction.

Citations

Jun 3, 2004·Journal of Cellular Physiology·Hongxiang HuiRiccardo Perfetti
Jul 20, 2007·Immunology and Cell Biology·Ayelet KaminitzNadir Askenasy
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diego G SilvaBrett Charlton
Dec 18, 2003·Annals of the New York Academy of Sciences·Diego G SilvaNikolai Petrovsky
Jan 26, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michal Pearl-YafeNadir Askenasy
Apr 4, 2021·International Journal of Molecular Sciences·Antonia Diaz-GaneteAlfonso M Lechuga-Sancho

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