The role of Fc-receptors in murine mercury-induced systemic autoimmunity.

Clinical and Experimental Immunology
Klara Martinsson, Per Hultman

Abstract

Inorganic mercury (Hg) in genetically susceptible mouse strains induces a T cell-dependent, systemic autoimmune condition (HgIA) characterized by immunostimulation, anti-nuclear antibodies (ANA) and systemic immune-complex (IC) deposits. The exact phenotypic expression of HgIA in different strains depends on H-2 and non-H-2 genes. Fc receptors (FcRs) are important in the development of many autoimmune diseases. In this study, the effect of targeted mutations for activating and inhibiting FcRs in the BALB/c model of HgIA was examined. Hg-treated BALB/c mice without mutation (wild-type, wt) showed heavy IC deposits in the renal glomerular mesangium, as well as in renal and splenic vessel walls. The renal mesangial IC deposits were severely reduced in Hg-treated BALB/c mice without the gamma-chain (lack of the activating receptors FcgammaRI, FcgammaRIII and FcinRI), but unchanged in mice lacking the inhibitory FcgammaRIIB. The Hg-induced vessel wall IC deposits present in wt mice were abolished and reduced in the FcRgamma and FcgammaRIIB strains, respectively. Hg-treated BALB/c wt mice and mice without the gamma-chain showed an increase in serum IgE, while the increase in IgG1 was attenuated in the latter strain. In contrast, abse...Continue Reading

References

Dec 5, 1990·Journal of Immunological Methods·R W Burlingame, R L Rubin
Nov 1, 1986·Toxicology and Applied Pharmacology·C J RobinsonI K Egorov
Nov 15, 1984·Experientia·S Eneström, P Hultman
Dec 1, 1995·Journal of Autoimmunity·P HultmanF Dagnaes-Hansen
Sep 17, 1998·The Journal of Clinical Investigation·S Y ParkT Saito
Sep 30, 1999·Environmental Health Perspectives·P E Bigazzi
May 3, 2000·The Journal of Experimental Medicine·S KleinauB Heyman
Mar 13, 2001·Annual Review of Immunology·J V Ravetch, S Bolland
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D H KonoK M Pollard
Aug 3, 2002·Nature Reviews. Immunology·Toshiyuki Takai
Oct 2, 2002·European Journal of Immunology·Teresita Díaz de StåhlSandra Kleinau
Feb 7, 2003·Arthritis and Rheumatism·Keiko MatsumotoTakashi Saito
Jul 23, 2003·Current Pharmaceutical Design·S Kleinau
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan Zheng, Marc Monestier
Jan 23, 2004·Toxicology and Applied Pharmacology·S HavarinasabP Hultman
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Michael PollardDwight H Kono
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan ZhengMarc Monestier
Jul 2, 2005·Autoimmunity Reviews·K Michael PollardDwight H Kono
Jul 6, 2005·Clinical and Experimental Immunology·Raphael ClynesHanno B Richards

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Citations

Jun 23, 2007·American Journal of Respiratory Cell and Molecular Biology·Agnieszka KrupaAnna K Kurdowska
Aug 31, 2007·Autoimmunity·Tatyana TarasenkoSilvia Bolland
Apr 6, 2007·Kidney International·M A Abrera-AbeledaS Sethi
Mar 4, 2008·Journal of Autoimmunity·Klara MartinssonPer Hultman
Dec 17, 2008·Annals of the New York Academy of Sciences·Jaya Vas, Marc Monestier
Sep 27, 2016·Autoimmunity Reviews·William CroweEmeir M McSorley
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sharmila FagooneeBenedetta Bussolati

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