The role of ferric carboxymaltose in the treatment of iron deficiency anemia in patients with gastrointestinal disease

Therapeutic Advances in Gastroenterology
Pramoda Koduru, Bincy P Abraham

Abstract

Iron deficiency anemia (IDA) is the most common form of nutritional anemia worldwide. Iron plays a pivotal role in vital functioning of almost every organ system. IDA affects both physical and psychological functioning of humans. Oral iron is considered as first-line therapy for the treatment of IDA due to low cost, good safety profile and ease of administration. However, the absorption of oral iron is affected by several factors and incidence of gastrointestinal side effects can lead to lack of adherence to therapy as well as poor efficacy. This has led to the emergence of intravenous iron therapy which is clearly superior to oral iron with higher increment of hemoglobin levels and rapid replenishment of iron stores. Ferric carboxymaltose (FCM) is a novel non-dextran intravenous iron form which has been approved for use in patients with iron deficiency who have had inadequate response to oral iron therapy, intolerance to oral iron, or nondialysis-dependent chronic kidney disease. The safety and efficacy of using FCM for the treatment of IDA has been demonstrated in several clinical trials. One dose can provide a large amount of iron and has a very short infusion time. It should be considered as first-line therapy in patients w...Continue Reading

References

Jan 1, 1978·Scandinavian Journal of Gastroenterology·U BartelsS Jarnum
Mar 1, 1975·Gut·P B DislerF Mayet
Mar 1, 1991·British Journal of Clinical Pharmacology·M KaraN R Campbell
May 1, 1987·The American Journal of Clinical Nutrition·L HallbergA B Skånberg
Mar 26, 1997·JAMA : the Journal of the American Medical Association·A C LookerC L Johnson
Aug 1, 1997·American Journal of Clinical Pathology·C BrugnaraO Platt
Aug 25, 1999·Journal of the American Academy of Dermatology·S R RappD M Reboussin
Dec 23, 1999·The New England Journal of Medicine·N C Andrews
Feb 28, 2002·Archives of Internal Medicine·Ephraim RimonZev M Sthoeger
Jul 13, 2004·Gut·C GascheG Weiss
Jan 31, 2006·Indian Journal of Medical Sciences·Kanjaksha Ghosh
Oct 18, 2006·European Journal of Haematology·Valeriu AtanasiuIrina Stoian
Nov 7, 2007·Inflammatory Bowel Diseases·Christoph GascheGert Van Assche
May 15, 2008·The American Journal of Gastroenterology·Javier P Gisbert, Fernando Gomollón
Dec 4, 2008·Haematologica·Chaim Hershko, Julian Patz
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ivana De DomenicoJerry Kaplan
May 2, 2009·Drugs·Katherine A Lyseng-Williamson, Gillian M Keating
Jul 25, 2009·The American Journal of Clinical Nutrition·Manuel RuzNancy F Krebs
Jun 10, 2010·World Journal of Gastroenterology : WJG·Ulas D Bayraktar, Soley Bayraktar
Jan 18, 2011·Hematology·Michael Auerbach, Harold Ballard
Feb 3, 2011·European Journal of Gastroenterology & Hepatology·Pantelis OustamanolakisElias A Kouroumalis
May 13, 2011·Gut·Andrew F GoddardUNKNOWN British Society of Gastroenterology
May 24, 2011·Inflammatory Bowel Diseases·James R GoodhandDavid S Rampton
Jun 22, 2012·Journal of the Academy of Nutrition and Dietetics·Lisa Tussing-HumphreysCarol Braunschweig
Oct 20, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rayko EvstatievUNKNOWN FERGI Study Group
Dec 21, 2012·Current Medical Research and Opinion·María Jesús Cancelo-HidalgoLluís Pérez-Edo
Jan 22, 2013·American Journal of Hematology·David B BregmanLawrence T Goodnough
Jun 15, 2013·Clinical and Experimental Gastroenterology·Neil D Goldberg
Jul 6, 2013·American Journal of Hematology·Michael AuerbachHuzefa Bahrain
Jul 23, 2013·Inflammatory Bowel Diseases·Gaetano BergamaschiGino Roberto Corazza
Jan 1, 2011·Pharmaceutics·Peter Geisser, Susanna Burckhardt
Jun 4, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Iain C MacdougallUNKNOWN FIND-CKD Study Investigators
Jul 16, 2014·Immunology and Allergy Clinics of North America·Andreas J Bircher, Michael Auerbach

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Citations

Jun 15, 2017·American Journal of Hematology·Maria Domenica CappelliniUNKNOWN IRON CORE Group
Jun 15, 2019·Alimentary Pharmacology & Therapeutics·Luis Ferrer-BarcelóEnrique Medina Chuliá
May 26, 2017·Der Internist·S von HaehlingS D Anker
Jan 30, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Michael H-G LiBernhard Riedel
Mar 28, 2020·United European Gastroenterology Journal
May 5, 2020·Frontiers in Medicine·Raquel Ballester-ClauMontse Planella de Rubinat
Sep 13, 2021·British Journal of Clinical Pharmacology·Giovanna CuledduDyfrig A Hughes

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