Abstract
To determine the role of the fibrinolytic and antifibrinolytic systems in HELLP syndrome. This study consisted of patients with HELLP Syndrome (study group, n = 17), women who were admitted for routine prenatal care (pregnant control group, n = 21) and those presenting for routine gynecologic examination (non-pregnant control group, n = 21). Plasma tissue-type plasminogen activator (tPA), thrombin-activatable fibrinolysis inhibitor (TAFI), plasminogen activator inhibitor-1 (PAI-1), thrombin-antithrombin complex (TAT) and thrombomodulin (TM) were measured at admission for all groups. They were again measured after 7 days of biochemical improvement in HELLP Syndrome group. The mean ages of women in the study, pregnant, and non-pregnant control groups were 29.82 ± 4.98, 29.71 ± 5.64, and 27.60 ± 4.21, respectively. Demographically, the patients in all three groups were similar with regard to maternal age, race, and body mass index. Compared to the control groups, the mean tPA, PAI-1, TAFI, TAT, and TM levels were significantly increased in HELLP Syndrome. The mean plasma TAFI antigen concentration 7 days after delivery was significantly lower compared to the baseline (5.84 ± 7.14 % change, p < 0.01). Significant decreases in the m...Continue Reading
References
Jun 16, 1995·The Journal of Biological Chemistry·L BajzarM E Nesheim
May 1, 1994·Geburtshilfe und Frauenheilkunde·M KolbenH Graeff
Oct 1, 1993·American Journal of Obstetrics and Gynecology·B M SibaiS A Friedman
Sep 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M KolbenH Tschesche
Aug 26, 1998·JAMA : the Journal of the American Medical Association·J H Stone
Jun 16, 1999·American Journal of Obstetrics and Gynecology·J N MartinP G Blake
Sep 29, 2001·Journal of Thrombosis and Thrombolysis·K Huber
Apr 12, 2002·The American Journal of Pathology·Yan ZhouSusan J Fisher
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·H Weiler, B H Isermann
Mar 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Patricia K AgatisaMargaret K McLaughlin
Sep 3, 2004·Thrombosis Research·Inci AlacacioğluBulent Undar
Nov 16, 2004·Thrombosis and Haemostasis·Hatem A MousaCheng-Hock Toh
Dec 2, 2004·Obstetrical & Gynecological Survey·Jason K Baxter, Louis Weinstein
Mar 10, 2006·Thrombosis and Haemostasis·Massimo Franchini
Apr 25, 2006·American Journal of Obstetrics and Gynecology·James N MartinChristian M Briery
May 9, 2006·Archives of Gynecology and Obstetrics·Ikuno KawabataToshiyuki Takeshita
Dec 23, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Luci Maria SantAna DusseBashir A Lwaleed
Dec 7, 2007·Journal of Thrombosis and Thrombolysis·Sabine MuetzeWerner Rath
Aug 13, 2008·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Pieter J van Runnard HeimelHein W Bruinse
Citations
Jul 18, 2012·Clinical and Experimental Hypertension : CHE·Gulsum OzkanOzlen Bektaş
Mar 7, 2014·Thrombosis Research·Sara OrnaghiMichael J Paidas
May 18, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kjell HaramOffer Erez
Aug 17, 2016·Hypertension·Luisa F Gomez-ArangoUNKNOWN SPRING Trial Group
Apr 11, 2017·Frontiers in Endocrinology·Suman MorampudiAnand Shanthanagowd Patil