The role of fibroblast growth factor 2 in drug addiction

The European Journal of Neuroscience
Oren Even-Chen, Segev Barak

Abstract

Fibroblast growth factor 2 (FGF2) is a member of the FGF-family, which consists of 22 members, with four known FGF receptors (five in humans). Over the last 30 years, FGF2 has been extensively studied for its role in cell proliferation, differentiation, growth, survival and angiogenesis during development, as well as for its role in adult neurogenesis and regenerative plasticity. Over the past decade, FGF2 has been implicated in learning and memory, as well as in several neuropsychiatric disorders, including anxiety, stress, depression and drug addiction. In this review, we present accumulating evidence indicating the involvement of FGF2 in neuroadaptations caused by drugs of abuse, namely, amphetamine, cocaine, nicotine and alcohol. Moreover, evidence suggests that FGF2 is a positive regulator of alcohol and drug-related behaviors. Thus, although additional studies are yet required, we suggest that reducing FGF2 activity may provide a novel therapeutic approach for substance use disorders.

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A J BeanT Hökfelt
Jan 1, 1987·Pharmacology & Therapeutics·R A Wise
Dec 1, 1993·Experimental Neurology·B J CummingsC W Cotman
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Mar 17, 2001·Nature Reviews. Neuroscience·E J Nestler
Jun 26, 2001·Clinical and Experimental Pharmacology & Physiology·M Ford-PerrissM Murphy
Jul 8, 2003·Cell and Tissue Research·Bernhard Reuss, Oliver von Bohlen und Halbach
Sep 18, 2003·Journal of Neuroscience Research·Fabio FumagalliMarco Andrea Riva
Oct 7, 2004·Neuropharmacology·Eric J Nestler
Apr 30, 2005·Trends in Pharmacological Sciences·Marco A RivaFabio Fumagalli
May 3, 2005·Cytokine & Growth Factor Reviews·V P EswarakumarJ Schlessinger
Apr 26, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aiqun LiJiawei Zhou
Jun 17, 2006·Annual Review of Neuroscience·Steven E HymanEric J Nestler
Jul 20, 2007·Developmental Neurobiology·Joseph PeltierDavid V Schaffer

❮ Previous
Next ❯

Citations

Jan 23, 2020·Cold Spring Harbor Perspectives in Medicine·Mirit LiranSegev Barak
Jan 6, 2021·International Journal of Molecular Sciences·Friederike Freiin von HövelClaudia Grothe
Aug 26, 2021·Neuroscience Letters·Eliyahu DremencovSaak V Ovsepian
Nov 20, 2021·Addiction Biology·Oren Even-ChenSegev Barak
Oct 14, 2020·Current Drug Targets·Shilpi AgrawalThallapuranam Krishnaswamy Suresh Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Sabrina ZechelO von Bohlen Und Halbach
Journal of Exercise Rehabilitation
Seung-Soo Baek
© 2022 Meta ULC. All rights reserved