Oct 30, 2018

The role of fibroblast growth factor signalling in Echinococcus multilocularis development and host-parasite interaction

BioRxiv : the Preprint Server for Biology
Sabine FörsterKlaus Brehm

Abstract

Background: Alveolar echinococcosis (AE) is a lethal zoonosis caused by the metacestode larva of the tapeworm Echinococcus multilocularis. The infection is characterized by tumour-like growth of the metacestode within the host liver, leading to extensive fibrosis and organ-failure. The molecular mechanisms of parasite organ tropism towards the liver and influences of liver cytokines and hormones on parasite development are little studied to date. Methodology/Principal findings: We show that the E. multilocularis larval stage expresses three members of the fibroblast growth factor (FGF) receptor family with homology to human FGF receptors. Using the Xenopus expression system we demonstrate that all three Echinococcus FGF receptors are activated in response to human acidic and basic FGF, which are present in the liver. In all three cases, activation could be prevented by addition of the tyrosine kinase inhibitor BIBF 1120, which is used to treat human cancer. At physiological concentrations, acidic and basic FGF significantly stimulated the formation of metacestode vesicles from parasite stem cells in vitro and supported metacestode growth. Furthermore, the parasite’s mitogen activated protein kinase signalling system was stimula...Continue Reading

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Mentioned in this Paper

Mitogen-Activated Protein Kinases
Fibroblast Growth Factor Receptors
Genus: Echinococcus
Neoplasms
Fibroblast Growth Factor Binding
Echinococcosis
BIBF 1000
Etiology
Larva
Mitogen-Activated Protein Kinase Kinases

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