PMID: 26807198Jan 26, 2016Paper

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma

Genes & Cancer
David J ElziYuzuru Shiio

Abstract

Ewing sarcoma is a cancer of bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets family transcription factor, most commonly FLI-1. The EWS-FLI-1 fusion oncogene is widely believed to play a central role in Ewing sarcoma. The EWS-FLI-1 gene product regulates the expression of a number of genes important for cancer progression, can transform mouse cells such as NIH3T3 and C3H10T1/2, and is necessary for proliferation and tumorigenicity of Ewing sarcoma cells, suggesting that EWS-FLI-1 is the causative oncogene. However, a variety of evidence also suggest that EWS-FLI-1 alone cannot fully explain the Ewing sarcomagenesis. Here we report that FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, is frequently expressed in Ewing sarcoma. We present evidence suggesting that endogenous FLI-1-EWS is required for Ewing sarcoma growth and that FLI-1-EWS cooperates with EWS-FLI-1 in human mesenchymal stem cells, putative cells of origin of Ewing sarcoma, through abrogation of the proliferation arrest induced by EWS- FLI-1.

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Citations

May 16, 2020·Frontiers in Oncology·Valentina Di RuscioAngela Mastronuzzi
May 26, 2017·Nucleic Acids Research·Gillian HsiehJulia Salzman
May 8, 2018·International Journal of Dermatology·Alejandra ToquicaRafael Parra-Medina
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Mar 7, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Samer SalahRamiz Abu Hijlih
Jul 23, 2018·Translational Research : the Journal of Laboratory and Clinical Medicine·Peng ZhangYong Zeng
Apr 25, 2021·Critical Reviews in Oncology/hematology·Veronica AranVivaldo Moura Neto
Aug 31, 2021·Genes, Chromosomes & Cancer·Mustafa SalimGudrun Göhring

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