The role of foregut exclusion in the deterioration of glucose and lipid metabolism induced by a high-fat diet

Diabetes Research and Clinical Practice
Pengzhou LiShaihong Zhu

Abstract

The small intestine may be involved in the improvement of glucose and lipid metabolism after bariatric surgery; however, the role of the foregut in metabolic changes remains unclear. This study used normal rats fed a high-fat diet (HFD) after bariatric surgery to determine the role of the foregut in glucose and lipid metabolism. Duodenum-jejunum bypass (DJB), gastrojejunostomy (GJ) and sham-operations were performed on Sprague-Dawley (SD) rats. Oral glucose tolerance, insulin sensitivity, β-cell function, lipid profile, glucose-stimulated glucose-dependent insulinotropic polypeptide (GIP) levels and glucagon-like peptide-1 (GLP-1) levels were measured. The rats were observed for 24 weeks post-surgery. Food intake and body weight were similar between the groups during the study period (P>0.05). The DJB group exhibited better glucose and lipid metabolism than the other groups (P<0.05). Compared with the GJ group, the DJB group demonstrated superior oral glucose tolerance, insulin sensitivity and lipid profiles (P<0.05); β-cell function in the two groups was similar (P>0.05). The GIP levels were decreased in the DJB group and increased in the GJ group (P<0.05), and the GLP-1 levels were increased in the DJB and GJ groups (P>0.05)....Continue Reading

References

Jan 1, 1986·Diabetologia·M NauckW Creutzfeldt
Jun 18, 2002·Nature Medicine·Kazumasa MiyawakiYutaka Seino
Sep 30, 2004·American Journal of Physiology. Endocrinology and Metabolism·April D StraderRandy J Seeley
Oct 14, 2004·JAMA : the Journal of the American Medical Association·Henry BuchwaldKaren Schoelles
Dec 26, 2006·The Journal of Clinical Investigation·Tanya HansotiaDaniel J Drucker
May 15, 2007·Gastroenterology·Laurie L Baggio, Daniel J Drucker
Mar 11, 2009·The American Journal of Medicine·Henry BuchwaldIsabella Sledge
Sep 15, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Nigel Irwin, Peter R Flatt
Nov 18, 2010·Obesity Surgery·Raghavendra S Rao, Subhash Kini
May 11, 2011·Diabetes, Obesity & Metabolism·O LindgrenB Ahrén
Sep 22, 2011·Diabetes Technology & Therapeutics·Brooke E BayhamCarol E O'Neil
Aug 24, 2012·The New England Journal of Medicine·Lena M S CarlssonLars Sjöström
Oct 25, 2012·American Journal of Physiology. Endocrinology and Metabolism·Katharina TimperMirjam Christ-Crain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.