The role of galanin and its receptor in the feedback regulation of growth hormone secretion

Endocrinology
Y Y ChanR A Steiner

Abstract

GH controls its own secretion through a mechanism involving short-loop feedback regulation of the synthesis and release of GH-releasing hormone (GHRH). GHRH neurons coexpress the peptide galanin, but the functional significance of this coexpression is unknown. In this study, we tested the hypotheses that 1) galanin gene expression in GHRH neurons is regulated by GH and 2) somatostatin (SS) or GHRH neurons are a target for the action of galanin in the hypothalamus. First, we compared levels of galanin messenger RNA (mRNA) in GHRH neurons between normal male rats and Lewis dwarf rats, which have markedly reduced blood levels of GH. The brains of normal and dwarf animals were processed for detection of galanin mRNA and GHRH mRNA by double-label in situ hybridization. We observed that Lewis dwarf rats had significantly reduced levels of galanin mRNA in their GHRH neurons (P < 0.05). Next, we tested the hypothesis that GH regulates galanin gene expression in GHRH neurons by experimentally altering circulating levels of GH. Three groups of adult male rats were used: 1) intact rats (n = 7); 2) hypophysectomized (hypox) rats (n = 7); and 3) hypox rats treated with 1.5 mg of rat GH (rGH) over a 3-day period (n = 6). At the end of the tr...Continue Reading

Citations

Dec 2, 2006·Journal of Chemical Neuroanatomy·Karine BouyerAnnie Faivre-Bauman
May 1, 1956·Archives of Biochemistry and Biophysics·R K MEYER, K H CLIFTON
Jan 12, 2001·Clinical and Experimental Pharmacology & Physiology·A L GundlachJ A Larm
May 2, 2001·The Journal of Comparative Neurology·S E PérezE J Mufson
Aug 21, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Vincenzo Cimini
Sep 11, 1998·The Journal of Comparative Neurology·M LandryT Hökfelt
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi

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