The role of gamma delta T cells in priming macrophages to produce tumor necrosis factor-alpha

European Journal of Immunology
H NishimuraY Yoshikai

Abstract

The secretion of tumor necrosis factor (TNF)-alpha from macrophages is regulated by both priming and triggering signals. We found that macrophages from mice lacking gamma delta T cells [T cell receptor (TCR) delta-/- mice], which lack the gene encoding the delta chain, produced only small amounts of TNF-alpha in response to lipopolysaccharide (LPS) and showed a reduced level of expression of CD14. Pre-incubation of macrophages from TCR delta-/- mice with gamma delta T cells from their TCR delta +/- littermates restored their capacity to produce TNF-alpha in response to LPS. The priming activity of gamma delta T cells was in part inhibited by neutralizing anti-interferon (IFN)-gamma monoclonal antibodies. Collectively, these results suggest that gamma delta T cells play a role in priming macrophages to a steady state of activation via IFN-gamma secretion, which allows them to produce TNF-alpha when exposed to LPS.

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Jan 1, 1992·The Journal of Experimental Medicine·K HiromatsuK Nomoto
Jan 1, 1986·Annual Review of Biochemistry·S Lindquist
Dec 1, 1989·Archives of Surgery·L Sanchez-CantuN V Christou
Jun 9, 1988·The New England Journal of Medicine·H R MichieD W Wilmore
May 1, 1987·Metabolism: Clinical and Experimental·C H Lang, J A Spitzer
May 1, 1994·The Journal of Experimental Medicine·K MatsuuraS Yamamoto
Mar 1, 1993·Immunology Today·H W Ziegler-Heitbrock, R J Ulevitch
May 1, 1994·The Journal of Experimental Medicine·B D CarB Ryffel
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·M TsujiS Tonegawa
Jan 1, 1993·Annual Review of Immunology·S H Kaufmann
Jan 1, 1993·Annual Review of Immunology·M A Farrar, R D Schreiber
Jan 1, 1993·Annual Review of Immunology·W HaasS Tonegawa

❮ Previous
Next ❯

Citations

Aug 1, 1996·Immunology Today·C AgostiniG Semenzato
Jan 25, 2003·Burns : Journal of the International Society for Burn Injuries·Martin G Schwacha
Feb 1, 1997·Current Opinion in Immunology·R Boismenu, W L Havran
Dec 14, 1999·Microbes and Infection·C T MoritaE Märker-Hermann
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·S H Kaufmann
Mar 29, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michelle AlexanderMartin G Schwacha
Aug 9, 2003·Critical Care Medicine·Alfred AyalaGrace Y Song
Aug 1, 1997·Immunological Reviews·S H KaufmannI E Flesch
Jun 24, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chun-Shiang ChungAlfred Ayala
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·A KanehiroE W Gelfand
Oct 28, 2008·Burns : Journal of the International Society for Burn Injuries·Martin G Schwacha
Jun 13, 2013·Innate Immunity·Martin G SchwachaAndre P Cap
May 24, 2000·The Annals of Otology, Rhinology, and Laryngology·K OlofssonM L Hammarström
Apr 2, 2014·European Journal of Immunology·Melvyn T ChowChristophe Paget
Jun 16, 2004·Journal of Leukocyte Biology·Balazs TothMartin G Schwacha
Oct 5, 2007·Journal of Leukocyte Biology·Fabienne VenetAlfred Ayala
Feb 26, 1999·The Journal of Urology·J Jones-CarsonD T Uehling
Jun 5, 2007·Shock·Tanjanika DanielMartin G Schwacha
Jan 26, 2008·Animal Health Research Reviews·Subramaniam SrikumaranAruna Ambagala
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T A MooreT J Standiford
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y MokunoY Yoshikai
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisheng WangJack F Bukowski
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B NikolicM Sykes
Mar 10, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·L NicolasJ Bienvenu

❮ Previous
Next ❯

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