The role of gender in salt-induced hypertension

Clinical and Experimental Hypertension : CHE
Mohamed A BayorhMyrtle Thierry-Palmer

Abstract

To evaluate gender differences in salt-induced hypertension, female and male Dahl salt-sensitive rats were fed high (8.0% NaCl, HS) and low (0.3% NaCl, LS) salt diets. During a 3-week treatment period, blood pressure was significantly elevated in both female and male HS groups compared to their respective LS groups. The blood pressure and 4 week mortality rate of the female HS group, however, were significantly lower than those of the male HS group. Renal and aortic blood flows were reduced in male rats on HS diet compared to the LS group, while, in females, renal blood flow was elevated and aortic flow was maintained while on HS diet. Plasma prostaglandin E2 and prostacyclin levels were higher in females than males and unaffected by diet. In contrast, plasma nitric oxide levels were reduced by HS, regardless of gender. In isolated aortic rings, HS diet caused a smaller elevation in the stimulated norepinephrine release ratio in female rats than in males. Thus, salt-induced hypertension is associated with a reduction in levels of nitric oxide regardless of gender. Plasma prostaglandin E2 and prostacyclin levels were higher in females. Taken together, the higher plasma prostaglandin levels and reduced sympathetic activity in fem...Continue Reading

References

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Citations

Aug 31, 2007·Clinical and Experimental Hypertension : CHE·Ryan G MorrisonWilliam D McCumbee
Aug 22, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Krairerk AthirakulDarryl C Zeldin
Apr 14, 2015·BioMed Research International·Fernando H G TessaroJoilson O Martins
Apr 16, 2016·Circulation Research·Christa L BlenckLeslie A Leinwand
Apr 11, 2008·American Journal of Physiology. Renal Physiology·David Z I CherneyJudith A Miller
Jan 25, 2003·Clinical and Experimental Pharmacology & Physiology·Janell Thompson, Raouf A Khalil
Feb 9, 2005·Hypertension·Jennifer C SullivanJennifer S Pollock
Aug 1, 2012·Physiological Research·J ZichaJ Kuneš
Jul 24, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Mikano SatoShinichiro Kokubun

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