The role of genotype in determining the effects of cigarette smoking on pulmonary function

Genetic Epidemiology
Peter V TishlerRichard R Fabsitz

Abstract

The effect of cigarette smoking on pulmonary function is highly variable. Some heavy smokers retain normal pulmonary function and others experience profound pulmonary function loss. The role of genotype in this process is unknown. We tested for gene by environment interaction (GxE) in smoking-associated loss of forced expiratory volume in one second (FEV1) using repeated pulmonary function and smoke-exposure measures from 352 twin pairs enrolled in the NHLBI Male Veteran Twin Study. Inferences using global [Jinks and Fulker, 1970] and dichotomous [Ramakrishnan et al., 1992] procedures were supplemented with a new model for repeatedly observed twinships. The model facilitates testing of standard heritability hypotheses and families of hypotheses regarding the dependence of quantitative twin-twin phenotypic similarity on continuously varying twin-twin exposure concordance. The global and dichotomous procedures were suggestive of GxE in smoke-associated loss of FEV1 (p < 0.01, p = 0.08, respectively). With the new model, overall twin-twin correlation of FEV1 for concordant-smoking MZ and DZ twin pairs was estimated at 0.71 and 0.34, respectively. For twins with little or no difference in cigarette use, the intra-pair correlations ...Continue Reading

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Citations

Jun 9, 2004·American Journal of Respiratory and Critical Care Medicine·Jian-Qing HeAndrew J Sandford
Jul 8, 2010·Respiratory Research·Jenny HallbergMagnus Svartengren
Nov 19, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Cristina AndreoliAntonella Bassi
Sep 9, 2009·Chest·Emily S Wan, Edwin K Silverman
Mar 24, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X LiuX Wang
Jun 15, 2010·Respiratory Medicine·Truls IngebrigtsenVibeke Backer
Mar 6, 2012·Free Radical Biology & Medicine·Amy R BentleyUNKNOWN Health, Aging, Body Composition Study
Nov 8, 2011·Respiratory Medicine·Bram van den BorstMaurice P Zeegers

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