PMID: 40119Jan 1, 1979

The role of glucocorticoid hormones as biological amplifiers

Monographs on Endocrinology
D K Granner

Abstract

Recent research in hormone action has been aimed at studying single effects in well-defined systems. As exemplified in several chapters of this book, it has been possible to deduce a general mechanism of action of the glucocorticoids using this approach. Most hormones, and the glucocorticoids in particular, do not act as independent agents in the intact animal. Although the best known example of how glucocorticoids interact with other hormones is the amplification of the effect of those whose action is mediated by cAMP, these steroids also augment the effects of a variety of other hormones and effectors. Such interactions are of interest in clinical medicine as well, since glucocorticoid hormones are used in combination with other drugs in a number of conditions, including the treatment of asthma, allergies, and certain kinds of shock and cancer. Neither the biochemical nor the pharmacologic basis for the effects of the glucocorticoids is known. In some cases the actions of other hormones are not observed unless the tissue has first been exposed to glucocorticoids. In these instances the glucocorticoids are said to exert a "permissive effect," since they allow a process to proceed at a maximal rate even though the steroid itsel...Continue Reading

Citations

Aug 9, 2002·American Journal of Physiology. Renal Physiology·Jelena KlisicPatrice M Ambühl
Mar 1, 1986·British Journal of Clinical Pharmacology·J EdelmanL P Hackett

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