PMID: 40119Jan 1, 1979

The role of glucocorticoid hormones as biological amplifiers

Monographs on Endocrinology
D K Granner


Recent research in hormone action has been aimed at studying single effects in well-defined systems. As exemplified in several chapters of this book, it has been possible to deduce a general mechanism of action of the glucocorticoids using this approach. Most hormones, and the glucocorticoids in particular, do not act as independent agents in the intact animal. Although the best known example of how glucocorticoids interact with other hormones is the amplification of the effect of those whose action is mediated by cAMP, these steroids also augment the effects of a variety of other hormones and effectors. Such interactions are of interest in clinical medicine as well, since glucocorticoid hormones are used in combination with other drugs in a number of conditions, including the treatment of asthma, allergies, and certain kinds of shock and cancer. Neither the biochemical nor the pharmacologic basis for the effects of the glucocorticoids is known. In some cases the actions of other hormones are not observed unless the tissue has first been exposed to glucocorticoids. In these instances the glucocorticoids are said to exert a "permissive effect," since they allow a process to proceed at a maximal rate even though the steroid itsel...Continue Reading


Aug 9, 2002·American Journal of Physiology. Renal Physiology·Jelena KlisicPatrice M Ambühl
Mar 1, 1986·British Journal of Clinical Pharmacology·J EdelmanL P Hackett

Related Concepts

Cyclic AMP, (R)-Isomer
Bucladesine, Barium (1: 1) Salt
Enzyme Induction
Glucocorticoid Effect
Hepatoma, Novikoff
Protein KINASE
Tyrosine Aminotransferase

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Behavioral and Brain Sciences
Nina Strohminger, Bradley W Moore
Baillière's Clinical Endocrinology and Metabolism
G R Williams, J A Franklyn
Methods in Molecular Biology
W A Harwood, D R Davies
© 2021 Meta ULC. All rights reserved