PMID: 8993728Nov 1, 1996Paper

The role of glucocorticoids in the management of asthma

Allergy and Asthma Proceedings
J D Spahn, D Y Leung

Abstract

Glucocorticoids (GCs) are a highly effective class of medication used in the treatment of airway inflammation associated with chronic asthma. Nevertheless, there remain concerns regarding potential adverse effects accompanying the use of systemic and high-dose inhaled GC therapy. Recent studies also suggest that there is high variability in airway response to GCs. Indeed, the immunopathogenesis of a subset of asthmatics poorly responsive to glucocorticoid therapy have been studied and may provide new insights into mechanisms by which glucocorticoids act in chronic asthma. The current review will examine a number of these issues, particularly mechanisms by which GCs act in asthma, the immunology of steroid resistance, and adverse effects associated with GC treatment.

Citations

Feb 2, 1999·Mediators of Inflammation·K GourgoulianisP A Molyvdas
Oct 3, 2006·Current Opinion in Anaesthesiology·W Habre
Jan 1, 2004·Current Therapeutic Research, Clinical and Experimental·Mark H GotfriedLarry H Danziger
Sep 27, 2007·Journal of Pharmacological Sciences·Gunnur Ozbakis DengizHalis Suleyman
Sep 6, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G M GauvreauP M O'Byrne
Apr 24, 2004·The Cochrane Database of Systematic Reviews·F DucharmeR Kakuma
Sep 25, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·E R DixonD B Lew
May 18, 2012·The Cochrane Database of Systematic Reviews·Bhupendrasinh F Chauhan, Francine M Ducharme

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