PMID: 2120153Aug 1, 1990Paper

The role of glucose-6-phosphate dehydrogenase in the evolution of longevity in Drosophila melanogaster

Heredity
L S LuckinbillT A Grudzien

Abstract

Different polymorphic elements of the enzyme glucose-6-phosphate dehydrogenase (G6PD) are favoured under selection for long versus short life span. Replicate independently selected populations of short-lived individuals exhibit a more rapidly migrating and less actively staining allozyme, while long-lived populations have a slower migrating and more active allozyme. These correspond to the common ZwA and ZwB variants of the G6PD locus Zw. In vitro measurements show G6PD activity varies with allozymes and life span. Long-lived males have 64 per cent greater activity in G6PD, while females of long-lived strains are 108 per cent higher than those of short-lived strains. Previous studies of these strains have repeatedly demonstrated additivity of life span in F1 crosses. Activity of G6PD in reciprocal F1 populations is additive and intermediate between parents.

References

Sep 7, 1985·Lancet·T J Wood, S E Thomas
Jun 1, 1988·Heredity·L S LuckinbillS Koetsawang
Aug 1, 1985·Heredity·L S Luckinbill, M J Clare
Jan 1, 1973·Annual Review of Genetics·J C Lucchesi
Apr 1, 1974·Experimental Gerontology·F A Lints, C Hoste
Sep 1, 1966·Journal of Theoretical Biology·W D Hamilton
May 1, 1980·Mechanisms of Ageing and Development·J R Flanagan
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D R Cavener, M T Clegg
Jun 1, 1954·The Quarterly Review of Biology·L C COLE
Sep 1, 1984·Evolution; International Journal of Organic Evolution·Leo S LuckinbillSteven A Buck
Sep 1, 1984·Evolution; International Journal of Organic Evolution·Michael R Rose
Jul 1, 1988·Evolution; International Journal of Organic Evolution·P M ServiceM R Rose
Jun 1, 1968·Evolution; International Journal of Organic Evolution·J M Wattiaux

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Citations

Jan 1, 1996·Experimental Gerontology·G M Martin
Jan 19, 2000·Neurobiology of Aging·T L ParkesJ P Phillips
Feb 10, 1999·Experimental Gerontology·S M Jazwinski
Jun 26, 1999·Heredity·B J Zwaan
Feb 19, 2008·Journal of Forensic Sciences·Walter H BirkbyBruce E Anderson
Sep 3, 2005·Experimental Gerontology·Matthew D W PiperLinda Partridge
Sep 21, 2010·Experimental Gerontology·Michael R Rose, Molly K Burke
Feb 28, 2019·Aging Cell·Lifen WangHeinrich Jasper
May 28, 2019·Journal of Cellular Biochemistry·Bor Luen Tang
Oct 9, 2020·Ageing Research Reviews·Andrey A ParkhitkoNorbert Perrimon

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