PMID: 8614610Apr 1, 1996Paper

The role of glutamine, short-chain fatty acids, and nucleotides in intestinal adaptation to gastrointestinal disease

Pediatric Clinics of North America
N S LeLeiko, M J Walsh

Abstract

Important first steps have been taken towards establishing how some nutrients interact with genes and affect intestinal adaptation. These mechanisms may be typical of how other nutrients influence cell function and turnover and help to maintain intestinal integrity. The dietary effects of nucleotides on intestinal cell mucosa act at the gene transcription level. The dietary effects of nucleotides on immune suppression also may act through similar mechanisms. The effects of the other trophic agents may interact at this level or at other levels. Scientific interest in how the various tropic factors work to maintain and repair the gastrointestinal tract is manifested by a growing body of research that demonstrates potential mechanisms for nutrient-gene interaction and how much interactions affect intestinal development and turnover. It seems clear that intestinal gene transcription and the activity of transcription factors are at least sometimes directly related to nutrition. The techniques of molecular biology now permit the exploration and explanation of how dietary factors, such as glutamine, SCFAs, and nucleotides, affect normal and pathologic intestinal mucosal development, function, adaptation, and repair.

References

Jan 1, 1977·The British Journal of Nutrition·S Jacobson, Wester P-O
Jun 22, 1978·The New England Journal of Medicine·R C Williamson
Nov 21, 1978·Biochimica Et Biophysica Acta·T Sonoda, M Tatibana
May 1, 1976·Canadian Journal of Biochemistry·P W BurridgeJ F Henderson
Jun 1, 1975·Archives of Surgery·Y KogaN Hashimoto
Mar 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·H TamadaA Okada
May 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·H JyonouchiR A Good
Jul 1, 1992·Gastroenterology·W A Rowe, T M Bayless
Jan 1, 1991·Annual Review of Nutrition·W W Souba
Aug 1, 1990·Nutrition Reviews·J M Lacey, D W Wilmore
Jul 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·R J Smith, D W Wilmore
Nov 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·M C NuñezA Gil
Jan 1, 1990·Digestive Diseases·B S Ramakrishna, W E Roediger
Jan 1, 1990·The Journal of Surgical Research·W W SoubaE M Copeland
May 1, 1990·Journal of Pediatric Gastroenterology and Nutrition·R UauyR Quan
Sep 1, 1990·Gastroenterology·J H Sellin, R DeSoignie
Nov 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·S T O'DwyerD W Wilmore
Aug 1, 1989·Metabolism: Clinical and Experimental·N BulusN N Abumrad
Jan 5, 1989·The New England Journal of Medicine·J M HarigC M Wood
Dec 1, 1985·Transplantation·C T Van BurenF B Rudolph
Jul 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·A D FoxJ L Rombeau
Jul 1, 1988·The Journal of Trauma·J W BakerR D Specian
Jan 1, 1987·Journal of Pediatric Gastroenterology and Nutrition·K HaffenP Simon-Assmann
Nov 1, 1985·The Biochemical Journal·M S Ardawi, E A Newsholme
Aug 10, 1973·Biochimica Et Biophysica Acta·A M Mackinnon, D J Deller
Jul 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·A F HopperP A McGovern
Sep 1, 1983·Transplantation·C T Van BurenF B Rudolph
Jul 14, 1982·Biochimica Et Biophysica Acta·N M Bradford, J D McGivan

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Citations

Jan 4, 2001·The Journal of Nutritional Biochemistry·C R CavaglieriR Curi
Oct 18, 2000·Journal of Clinical Gastroenterology·Z A MakhdoomC D Still
Sep 2, 2010·World Journal of Gastroenterology : WJG·Tzou-Chi HuangKuo Pin Chuang
Oct 14, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J J BozaO Ballèvre
Jan 23, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·S KleinJ L Rombeau
Jun 1, 1998·The Veterinary Quarterly·W von EngelhardtR Busche
Aug 27, 2019·Evolution & Development·Nicholas A Levis, David W Pfennig
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E C Claud, W A Walker
Apr 27, 2002·The American Journal of Clinical Nutrition·David H Alpers
Sep 28, 1999·Scandinavian Journal of Gastroenterology. Supplement·B J GeerlingR J Brummer

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