The role of glutathione in cancer

Cell Biochemistry and Function
Ganesaratnam K BalendiranDeborah Fraser

Abstract

Glutathione is an abundant natural tripeptide found within almost all cells. Glutathione is highly reactive and is often found conjugated to other molecules via its sulfhydryl moiety. It instils several vital roles within a cell including antioxidation, maintenance of the redox state, modulation of the immune response and detoxification of xenobiotics. With respect to cancer, glutathione metabolism is able to play both protective and pathogenic roles. It is crucial in the removal and detoxification of carcinogens, and alterations in this pathway, can have a profound effect on cell survival. However, by conferring resistance to a number of chemotherapeutic drugs, elevated levels of glutathione in tumour cells are able to protect such cells in bone marrow, breast, colon, larynx and lung cancers. Here we present a number of studies investigating the role of glutathione in promoting cancer, impeding chemotherapy, and the use of glutathione modulation to enhance anti-neoplastic therapy.

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·O W GriffithA Meister
Jan 1, 1978·International Review of Cytology·N S Kosower, E M Kosower
Jul 8, 1975·Biochemical and Biophysical Research Communications·J D SchulmanE J Butler
Oct 1, 1978·Journal of Molecular and Cellular Cardiology·N W Revis, N Marusic
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·R A BrittenH M Warenius
Nov 1, 1992·Trends in Biochemical Sciences·T Ishikawa
Jan 1, 1992·Critical Reviews in Toxicology·T J Monks, S S Lau
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·A D LewisB I Sikic
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M SuthanthiranA Meister
Oct 1, 1990·Toxicology and Applied Pharmacology·T J MonksP J van Bladeren
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J SeidegårdW R Pearson
Jan 1, 1985·Annual Review of Pharmacology and Toxicology·N KaplowitzM Ookhtens
Mar 1, 1995·Carcinogenesis·T P MulderA Wiersma
Mar 1, 1995·Leukemia & Lymphoma·F JoncourtT Cerny
Jan 1, 1994·Advances in Pharmacology·T J Monks, S S Lau
Jan 1, 1994·The American Journal of Clinical Nutrition·M Toborek, B Hennig
Dec 10, 1997·Journal of the National Cancer Institute·H H BaileyG Wilding
Jul 29, 1998·Chemico-biological Interactions·E Ristoff, A Larsson
Jul 29, 1998·Chemico-biological Interactions·X ChenG Batist
Jul 10, 1999·International Journal of Cancer. Journal International Du Cancer·T IidaT Kondo
Jul 23, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·D L Eaton, T K Bammler
Oct 30, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·T J MonksE A Lock
May 18, 2000·Biochemical Society Transactions·D Sheehan, G Meade
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Z Z HuangS C Lu
Mar 10, 2001·International Journal of Radiation Oncology, Biology, Physics·L N NguyenR D Meyn

❮ Previous
Next ❯

Citations

Sep 28, 2007·Breast Cancer Research and Treatment·Vanesa MartinezLorraine O'Driscoll
May 12, 2011·Breast Cancer Research and Treatment·Katherine M AirdGayathri R Devi
Jun 8, 2013·Cell Biology and Toxicology·Cheng PengJack C Ng
Oct 1, 2013·Neuroscience Letters·A N Lozano-OndouaT W Vanderah
Mar 18, 2009·Journal of the American Chemical Society·Akamol KlaikherdS Thayumanavan
Aug 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sarah J DouganPeter J Sadler
Nov 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kayvan R KeshariDavid M Wilson
Apr 5, 2011·Nutrition and Cancer·John P RichieKaram El-Bayoumy
Feb 28, 2013·Nutrition and Cancer·Fatemeh T ShamsabadiSuhaila Mohamed
Sep 24, 2011·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Rafael Andres IbarraJ R Sanabria
Jan 26, 2007·BMC Cancer·Sang-Geun JangJae-Gahb Park
Nov 26, 2008·BioData Mining·Kristian OvaskaSampsa Hautaniemi
Jan 27, 2009·Biological Chemistry·Nazzareno BallatoriChristine L Hammond
Jul 15, 2011·Interdisciplinary Toxicology·Ivana HaluzováZdeňka Svobodová
Feb 8, 2014·Colloids and Surfaces. B, Biointerfaces·Weifeng LinShengfu Chen
Jun 20, 2012·Annual Review of Analytical Chemistry·Robin L McCarley
May 24, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Daniela ZaniniMaria Rosa Chitolina Schetinger
Aug 30, 2014·Chemico-biological Interactions·Eri FukunagaYasuo Oyama
Jun 2, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ann ButcherGabrielle Heilek
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Weiren ChengYe Liu
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Eric P SeidlitzGurmit Singh
Feb 2, 2013·Canadian Journal of Physiology and Pharmacology·Robert G UngardGurmit Singh
May 1, 2013·Journal of Medicinal Chemistry·Amanda L WolfeDale L Boger
Mar 7, 2006·Critical Reviews in Clinical Laboratory Sciences·José M EstrelaElena Obrador
Jan 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela Hartmann JornadaMan Chin Chung
Jul 22, 2008·Drug Metabolism Reviews·Dianne BottaTerrance J Kavanagh
Dec 7, 2013·Cancer Investigation·Murat KoçerTolga Taha Sönmez
Dec 26, 2007·Archives of Physiology and Biochemistry·R FrancoM I Panayiotidis
May 14, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aditi JhaveriVladimir Torchilin
Jun 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lorine BrülisauerJean-Christophe Leroux

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annual Review of Biochemistry
A Meister, M E Anderson
Annual Review of Pharmacology and Toxicology
John D HayesIan R Jowsey
Biochemical Pharmacology
Alfonso PompellaAlessandro F Casini
© 2021 Meta ULC. All rights reserved