The role of glutathione in the transport and catabolism of nitric oxide

FEBS Letters
N HoggB Kalyanaraman

Abstract

Nitric oxide acts as a neuronal and vascular messenger implying diffusion through intracellular environments containing 5-10 mM glutathione. Nitric oxide reacts with glutathione under aerobic conditions generating S-nitrosoglutathione (GSNO). GSNO reacts with glutathione (k= 8.3 X 10(-3) M-1 X s-1) to generate nitrous oxide and glutathione disulfide (GSSG). Anaerobically, glutathione reacts with nitric oxide generating nitrous oxide and GSSG (k= 4.8 X 10(-4) s-1 at 5 mM GSH). In both aerobic and anaerobic situations the nitroxyl anion may be an intermediate in the synthesis of nitrous oxide and, under aerobic conditions, nitroxyl anion may generate peroxynitrite. We present a hypothesis for the intracellular interaction between nitric oxide and glutathione.

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J S StamlerJ Loscalzo
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J S StamlerJ Loscalzo
Oct 20, 1995·Archives of Biochemistry and Biophysics·Y TakeharaK Utsumi
May 30, 1995·Biochemistry·D PietraforteM Minetti
Mar 3, 1994·Nature·M FeelischS Moncada
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B GastonD J Singel
Nov 15, 1993·Biochemical and Biophysical Research Communications·A MülschR Busse
Apr 30, 1993·Biochemical and Biophysical Research Communications·J JosephJ S Hyde
Mar 29, 1993·FEBS Letters·P Girard, P Potier
Dec 1, 1995·Free Radical Biology & Medicine·G Czapski, S Goldstein

❮ Previous
Next ❯

Citations

Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NishikawaM Inoue
Nov 24, 1999·Archives of Biochemistry and Biophysics·R J SinghB Kalyanaraman
Nov 30, 2000·Archives of Biochemistry and Biophysics·R J Mallis, J A Thomas
Jul 19, 2005·Archives of Microbiology·Yancheng LiuShaoyi Huang
Jan 31, 2004·Current Oncology Reports·David Hamilton, Gerald Batist
Mar 17, 2004·Biomaterials·Amedea Barozzi Seabra, Marcelo Ganzarolli De Oliveira
Dec 4, 2003·Free Radical Biology & Medicine·Netanya Y SpencerNeil Hogg
Apr 3, 2004·Free Radical Biology & Medicine·Yanhong Zhang, Neil Hogg
Aug 21, 2003·Ecotoxicology and Environmental Safety·Wei-min LiLian-sheng Wang
Aug 6, 2000·Free Radical Biology & Medicine·N Hogg
Aug 12, 2000·Free Radical Biology & Medicine·E A KonorevN Hogg
Apr 10, 2003·Free Radical Biology & Medicine·Astrid SchrammelBernd Mayer
Feb 24, 2001·Bioorganic & Medicinal Chemistry Letters·K WangP G Wang
Sep 18, 2010·Chemical Research in Toxicology·Nicholas J Kettenhofen, Matthew J Wood
May 23, 2001·The Biochemical Journal·M SteffenC Giulivi
Jun 8, 2001·The Biochemical Journal·F MisitiI Messana
Jul 26, 2003·Antioxidants & Redox Signaling·Nikola J CostaMichael P Murphy
Sep 4, 2010·Antioxidants & Redox Signaling·Jan Lewerenz, Pamela Maher
Jan 18, 2011·Antioxidants & Redox Signaling·Wilmarie Flores-SantanaDavid A Wink
Feb 24, 2012·Antioxidants & Redox Signaling·Erika Bechtold, S Bruce King
Apr 4, 2012·Antioxidants & Redox Signaling·Katarzyna A Broniowska, Neil Hogg
Sep 3, 2004·Japanese Journal of Clinical Oncology·S Syed Sultan BeeviA Geetha
Jun 22, 2002·Annals of the New York Academy of Sciences·Philip K LiuAlex Valadka
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·K L DavisF Murad
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Neil Hogg
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Partha MukhopadhyayPál Pacher
Jan 8, 2004·Biological & Pharmaceutical Bulletin·Kiyomi KikugawaTakumi Ohkawa
Dec 24, 1997·Environmental Health Perspectives·M DörgerF Krombach
May 10, 2013·PLoS Computational Biology·Jonathan L Robinson, Mark P Brynildsen
Jan 5, 2011·PloS One·Frances L Jourd'heuilDavid Jourd'heuil
Oct 23, 2013·International Journal of Molecular Sciences·Koji Aoyama, Toshio Nakaki
Sep 1, 2000·Journal of Molecular and Cellular Cardiology·P Y CheungR Schulz
May 15, 2015·Biomolecules·Nikolaus Bresgen, Peter M Eckl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.