The role of glutathione metabolism in tolerance of tobacco BY-2 suspension cells to microcystin-RR

Bulletin of Environmental Contamination and Toxicology
Wen Min HuangYong Ding Liu

Abstract

This study was undertaken to investigate the role of the glutathione-involved detoxifying mechanism in defending the tobacco BY-2 suspension cells against microcystin-RR (MC-RR). Analysis showed that exposure of the cells to different concentrations of MC-RR (0.1, 1 and 10 microg/mL) for 0-6 days resulted in a time and concentration-dependent decrease in cell viability and increase in reactive oxygen species (ROS) content. Reduced glutathione (GSH) and total glutathione (tGSH) content as well as glutathione reductase (GR), glutathione peroxidase (GPX) and glutathione-S-transferase (GST) activities significantly increased after 3-4 days exposure in the highest two concentration treated groups, while decreased until reaching the control values except for GPX at day 6. Oxidized glutathione (GSSG) content markedly increased compared with control in high concentration MC-RR treated group after 6 days exposure. The GSH/GSSG ratio was much higher than control in 10 microg/mL MC-RR treated group at day 4, but after 6 days exposure, the ratios in all treated groups were lower than that of the control group.

References

May 6, 2003·Chemosphere·Shamama HaiderPoonam Kakkar
Jun 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Michelle M GehringerTim G Downing
Jun 7, 2005·Ageing Research Reviews·Pamela Maher
Aug 9, 2005·Toxicon : Official Journal of the International Society on Toxinology·Liyan YinYongding Liu

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Citations

Apr 15, 2011·Journal of Lipids·Keisuke Obara, Yoshinori Ohsumi
Sep 7, 2014·Journal of Environmental Sciences (China)·Wenmin HuangYongding Liu
Sep 11, 2010·Plant Physiology and Biochemistry : PPB·Wei XingGuihua Liu
Mar 30, 2013·Toxicology Letters·Franca M BurattiEmanuela Testai
Dec 30, 2014·Ecotoxicology and Environmental Safety·De Lu ZhangYong Ding Liu
Nov 7, 2018·Environmental Research·Leticia Díez-QuijadaAna M Cameán
Mar 16, 2021·Dose-response : a Publication of International Hormesis Society·Yue HuangNaiyao Chen

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