The Role of Gluten in Celiac Disease and Type 1 Diabetes

Nutrients
Gloria SerenaAlessio Fasano

Abstract

Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established as the instigator of autoimmunity; the autoimmune process is halted by removing gluten from the diet; which allows for resolution of celiac autoimmune enteropathy and subsequent normalization of serological markers of the disease. However; an analogous causative agent has not yet been identified for T1D. Nevertheless; the role of dietary gluten in development of T1D and the potentially beneficial effect of removing gluten from the diet of patients with T1D are still debated. In this review; we discuss the comorbid occurrence of CD and T1D and explore current evidences for the specific role of gluten in both conditions; specifically focusing on current evidence on the effect of gluten on the immune system and the gut microbiota.

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Citations

Feb 1, 2017·Journal of Food Science·Jitendra KumarNar Singh Chauhan
Mar 28, 2018·International Journal of Molecular Sciences·Hui HanYulong Yin
Apr 11, 2018·Beneficial Microbes·T SakuraiJ-Z Xiao
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Jul 20, 2019·Current Allergy and Asthma Reports·Gloria SerenaAlessio Fasano
Oct 18, 2020·Healthcare·Diana Di LibertoMarianna Lauricella
Jan 22, 2021·Expert Review of Clinical Immunology·Paolo D'AvinoAlessio Fasano

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Methods Mentioned

BETA
biopsy
biopsies

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