The role of glycoproteins in calcium oxalate crystal development

BJU International
Felix GrasesAntonia Costa-Bauzá

Abstract

To assess the effects of a glycoprotein (mucine) on calcium oxalate crystal development in different conditions and situations, to clarify some of its possible effects. Crystallization was assessed using a batch system in presence of mucine suspensions, by kinetic-turbidimetric measurements, and using a flow system in the presence of retained agglomerates of mucine, evaluating the precipitated calcium oxalate. In batch conditions low mucine concentrations (<15 mg/L) inhibited calcium oxalate nucleation and higher concentrations (<250 mg/L) inhibited calcium phosphate nucleation, whereas at high concentrations there was also promotion. The presence of an aggregate of mucine in the flow system provoked calcium oxalate monohydrate crystallization at 0.691 microg/h per mg of mucine. In flow conditions pyrophosphate at 11.5 micromol/L caused a decrease of 84% in the calcium oxalate crystallized on mucine, 1.32 mmol/L of citrate a decrease of a 83%, 20 mg/L of pentosan polysulphate a decrease by 80%, and 7.58 micromol/L phytate totally prevented the crystallization of calcium oxalate on mucine. All substances inhibiting calcium oxalate crystallization with the capacity to interact with calcium ions also have crystallization promoting...Continue Reading

References

Feb 1, 1997·Clinical Biochemistry·M C RomeroA B Nesse
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Feb 1, 2000·Calcified Tissue International·S R KhanC Hammett-Stabler
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Apr 23, 2003·European Urology·Eiji KonyaTakashi Kurita

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Citations

Jul 14, 2010·Urological Research·Laurie B GowerSaeed R Khan
Jul 8, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Jonathan M Whittamore
Jul 11, 2006·BMC Urology·A Costa-BauzáF Grases
Mar 17, 2007·Scandinavian Journal of Urology and Nephrology·Félix GrasesAntònia Costa-Bauzá
Aug 15, 2014·Journal of the American Chemical Society·Sahar FarmaneshJeffrey D Rimer

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