The role of glycyrrhetinic acid modification on preparation and evaluation of quercetin-loaded chitosan-based self-aggregates

Journal of Colloid and Interface Science
Hongliang DuGuangxi Zhai

Abstract

Quercetin (QC), a type of plant-based chemical, has been reported to own anticancer activity in vivo. However, the poor water solubility limits its pharmaceutical application. In this study, two kinds of QC-loaded self-aggregates based on O-carboxymethyl chitosan-cholic acid conjugates (CMCA) were developed to improve the drug bioavailability in which glycyrrhetinic acid (GA) modification was utilized in the nanocarrier fabrication (QC-GA-CMCA) or not (QC-CMCA). These self-aggregates were prepared by a modified ultrasound-dialysis method and the role of GA modification on the evaluation of QC-loaded self-aggregates was investigated. Transmission Electron Microscopy (TEM) images revealed the formation of spherical particles of both self-aggregates. Dynamic Light Scattering (DLS) analysis and UV-VIS spectroscopy showed that the QC-GA-CMCA had smaller size, narrower size distribution, higher drug loading and entrapment efficiency than corresponding QC-CMCA aggregates. QC-GA-CMCA showed more obvious sensitivity to acidic pH condition based on the zeta potential measurements at various pHs, and fastest drug release was observed at pH 5.7 for QC-CMCA while at pH 6.5 for QC-GA-CMCA. In addition, QC-GA-CMCA demonstrated enhanced cell c...Continue Reading

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Citations

Mar 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Keru ZhangHaibing He
Oct 9, 2019·Advanced Pharmaceutical Bulletin·Jalil RashediBehzad Baradaran
Jan 13, 2018·Bioscience, Biotechnology, and Biochemistry·Zhen LuGuangxi Zhai
May 16, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Sedef İlkMurat Kaya
Apr 6, 2021·Bioactive Materials·Yujun ZengKui Luo
Jun 20, 2021·Carbohydrate Research·Tanaji Nandgude, Roshani Pagar

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