Abstract
Quercetin (QC), a type of plant-based chemical, has been reported to own anticancer activity in vivo. However, the poor water solubility limits its pharmaceutical application. In this study, two kinds of QC-loaded self-aggregates based on O-carboxymethyl chitosan-cholic acid conjugates (CMCA) were developed to improve the drug bioavailability in which glycyrrhetinic acid (GA) modification was utilized in the nanocarrier fabrication (QC-GA-CMCA) or not (QC-CMCA). These self-aggregates were prepared by a modified ultrasound-dialysis method and the role of GA modification on the evaluation of QC-loaded self-aggregates was investigated. Transmission Electron Microscopy (TEM) images revealed the formation of spherical particles of both self-aggregates. Dynamic Light Scattering (DLS) analysis and UV-VIS spectroscopy showed that the QC-GA-CMCA had smaller size, narrower size distribution, higher drug loading and entrapment efficiency than corresponding QC-CMCA aggregates. QC-GA-CMCA showed more obvious sensitivity to acidic pH condition based on the zeta potential measurements at various pHs, and fastest drug release was observed at pH 5.7 for QC-CMCA while at pH 6.5 for QC-GA-CMCA. In addition, QC-GA-CMCA demonstrated enhanced cell c...Continue Reading
References
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·K Y LeeS Y Jeong
Jan 26, 2005·European Journal of Immunology·Mònica ComaladaAntonio Zarzuelo
May 19, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhi-ping YuanYu-quan Wei
Dec 17, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H MaedaJ Daruwalla
Mar 23, 2010·Biomaterials·Qin TianHua Tang
May 5, 2010·Acta Biomaterialia·Wei HuangHua Tang
Nov 22, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Qin TianZhi Yuan
Mar 13, 2012·Colloids and Surfaces. B, Biointerfaces·Yun-Huan JinDa-Wei Chen
Apr 19, 2012·Experimental Dermatology·Shing-Chuan ShenYen-Chou Chen
May 18, 2012·Inflammation·Myung-Soon SungWan-Hee Yoo
Apr 1, 2010·Indian Journal of Clinical Biochemistry : IJCB·Mohamed Ahmed AbdelmoatyM A Abdelaziz
Nov 3, 2012·International Journal of Pharmaceutics·Li ZhangQiang Zhang
Dec 12, 2012·International Journal of Molecular Sciences·Jefree JohariKeivan Zandi
Jun 6, 2013·Immunobiology·Mehari EndaleMan Hee Rhee
Oct 3, 2013·Metallomics : Integrated Biometal Science·K Benjamin Garbutcheon-SinghJanice R Aldrich-Wright
Oct 9, 2013·Journal of Drug Targeting·Buyun DingGuangxi Zhai
Nov 14, 2013·International Journal of Pharmaceutics·Katarzyna Bury, Dorota Neugebauer
Jan 8, 2014·Journal of Pharmaceutical Sciences·Osama A A AhmedJihan M Badr
Jan 9, 2014·ACS Nano·Riham I El-GogaryKhuloud T Al-Jamal
Apr 8, 2014·Acta Biochimica Et Biophysica Sinica·Jie XiaoYudan Wu
May 16, 2014·Nanomedicine·Hongliang DuGuangxi Zhai
Jun 18, 2014·Nanoscale Research Letters·Wenjing LinLijuan Zhang
Jul 20, 2014·Carbohydrate Polymers·Hongliang DuGuangxi Zhai
Feb 25, 2015·Pharmacognosy Magazine·Hoda M EidPierre S Haddad
Citations
Jun 28, 2016·Colloids and Surfaces. B, Biointerfaces·Mengrui LiuGuangxi Zhai
Mar 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Keru ZhangHaibing He
Jun 6, 2019·Nanomedicine·Maimoona QindeelAsim U Rehman
Oct 9, 2019·Advanced Pharmaceutical Bulletin·Jalil RashediBehzad Baradaran
Jan 13, 2018·Bioscience, Biotechnology, and Biochemistry·Zhen LuGuangxi Zhai
May 16, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Sedef İlkMurat Kaya
Apr 6, 2021·Bioactive Materials·Yujun ZengKui Luo
May 2, 2021·International Journal of Biological Macromolecules·Elnaz NematollahiMona Navaei Nigjeh
Jun 20, 2021·Carbohydrate Research·Tanaji Nandgude, Roshani Pagar
Jul 24, 2021·Carbohydrate Polymers·Min LiShubiao Zhang