PMID: 8965325Mar 1, 1996Paper

The role of GM1-ganglioside in the injured spinal cord of rats: an immunohistochemical study using GM1-antisera

Journal of Neurotrauma
T ImanakaT Maeda

Abstract

The effect of GM1-ganglioside (GM1) administration was investigated in the injured spinal cord of rats. Immunohistochemistry using GM1-antisera was applied in the study of GM1 distribution, and locomotor recovery was also evaluated. A total of 86 rats, subdivided into four groups, were used in the study. The SI + GM1 group (n = 30) underwent a thoracic cord injury, and then received daily intraperitoneal injections of GM1 (10 mg/kg) from 0 to 13 days after injury. The SI group (n = 30) also underwent thoracic cord injury, but did not receive GM1 treatment. The GM1 group (n = 20) received daily injections of GM1 in the absence of any spinal cord injury. The control group (n = 6) neither underwent spinal cord injury nor received GM1 treatment. The animals were sacrificed at 1, 3, 5, 7, and 14 days after injury for immunohistochemical evaluation. GM1 immunoreactive axons, myelin sheaths, and glial cells were counted in 5 light microscopic fields of spinal white matter. Immunohistochemical studies of the spinal cord revealed that GM1 treatment significantly increased both GM1-positive axons and GM1-positive myelin sheaths in the lateral funiculus surrounding the lesion site. The exogenous GM1 was incorporated predominantly into the...Continue Reading

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Citations

Oct 5, 2001·Clinical Neuropharmacology·R J DumontA S Dumont
Jan 3, 2006·Journal of Neurologic Physical Therapy : JNPT·Maria J Amador, James D Guest
Oct 3, 2006·Current Opinion in Anaesthesiology·T Brüssel
Apr 3, 2020·Clinical Spine Surgery : a Spine Publication·Glenn S RussoGregory D Schroeder
Mar 30, 2017·Neurosurgery·Christopher S AhujaMichael G Fehlings

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