The role of GPCR signaling in cardiac Epithelial to Mesenchymal Transformation (EMT)

Trends in Cardiovascular Medicine
Canan G Nebigil, Laurent Désaubry

Abstract

Congenital heart disease is the most common birth defect, affecting 1.35 million newborns every year. Heart failure is a primary cause of late morbidity and mortality after myocardial infarction. Heart development is involved in several rounds of epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET). Errors in these processes contribute to congenital heart disease, and exert deleterious effects on the heart and circulation after myocardial infarction. The identification of factors that are involved in heart development and disease, and the development of new approaches for the treatment of these disorders are of great interest. G protein coupled receptors (GPCRs) comprise 40% of clinically used drug targets, and their signaling are vital components of the heart during development, cardiac repair and in cardiac disease pathogenesis. This review focuses on the importance of EMT program in the heart, and outlines the newly identified GPCRs as potential therapeutic targets of reprogramming EMT to support cardiac cell fate during heart development and after myocardial infarction. More specifically we discuss prokineticin, serotonin, sphingosine-1-phosphate and apelin receptors in heart development...Continue Reading

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Citations

Jul 11, 2020·Expert Opinion on Drug Discovery·Andrey D BondarevHelgi B Schiöth
Dec 17, 2019·Current Molecular Medicine·Esraa HajiSameer Mohammad
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Sep 24, 2019·JACC. CardioOncology·Emilio Hirsch

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