The role of graft and host accommodation in a hamster-to-rat cardiac transplantation model

Transplantation
Koji KomoriMasaki Kitajima

Abstract

We evaluated the importance and mechanism of graft and host accommodation in hamster-to-rat cardiac xenotransplantation models. To evaluate graft accommodation, accommodated hamster grafts (Group 2) were transplanted to naïve host rats treated with FK506, and compared with naïve hamster grafts (Group 1). To evaluate host accommodation, three groups were evaluated: naive hamster hearts were transplanted to naïve hosts treated with FK506 (Group 3: 0.5 mg/kg, Group 4: 1.0 mg/kg) and splenectomy, and compared with accommodating hosts (Group 5) with FK506 0.5 mg/kg and splenectomy. We examined graft survival, histopathology, antihamster antibodies and B-1 cells in blood. Graft survival in Group 2 (3.4+/-0.9 days) was not significantly different from that in Group 1 (2.8+/-0.4 days). Graft survival in Groups 4 and 5 (>30 days) was significantly prolonged compared with that in Group 3 (6.0+/-0.7 days). Histopathology of Groups 1-3 showed humoral rejection, whereas Groups 4 and 5 showed normal histology and expression of protective genes. In Groups 1-3, antihamster immunoglobulin (Ig) M and B-1 cells increased significantly compared to Groups 4 and 5, where IgM and B-1 cells remained low or were reduced. Host accommodation was more imp...Continue Reading

References

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Aug 24, 2006·Xenotransplantation·Georg StussiJörg D Seebach

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Citations

Dec 9, 2008·Current Opinion in Organ Transplantation·Burcin Ekser, David Kc Cooper
Jul 10, 2008·Xenotransplantation·Reto M Baertschiger, Leo H Buhler
Nov 5, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Dorling
Aug 3, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hee Jung JeonJaeseok Yang
Mar 25, 2009·Current Opinion in Organ Transplantation

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