The role of group I metabotropic glutamate receptors in memory consolidation and reconsolidation in the passive avoidance task in 1-day-old chicks

Neurochemistry International
Elzbieta Salinska

Abstract

Although reconsolidation of memory after reminder does not seem to be the simple reiteration of the sequential stages occurring during memory consolidation, both phenomena probably employ similar mechanisms including activation of glutamate receptors and protein synthesis. It is known that group I metabotropic glutamate receptors (mGluRs) are involved in memory consolidation and modulation of protein synthesis. The aim of present study was to investigate the role of mGluR5 in memory consolidation and reconsolidation and to determine whether inhibition of these receptors may affect protein synthesis in these processes. The one-trial passive avoidance task on chicks was used as the experimental model of learning. Injection of the mGluR5 antagonist MPEP into a specific chick brain region IMM resulted in amnesia, provided the injection was made either shortly before or after training, or approximately 4 h after training. This amnesia was permanent, resembling the effects of protein synthesis inhibitors. MPEP injection immediately after reminder resulted in only a transient amnesia revealed 1h later. Increased expression of Zif/268 and c-Fos proteins 2 h after initial training was abolished bilaterally in chicks injected with MPEP. ...Continue Reading

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Citations

May 4, 2013·Neuroscience and Biobehavioral Reviews·Kathryn D BakerNikki S Rickard
Aug 11, 2012·Progress in Neurobiology·Antoine BesnardSerge Laroche
Apr 10, 2012·Neuroscience and Biobehavioral Reviews·Peter S B Finnie, Karim Nader
Apr 7, 2010·European Journal of Pharmacology·Agnes SimonyiGert R J Christoffersen
Apr 16, 2008·European Journal of Pharmacology·Leontien DiergaardeTaco J De Vries
May 23, 2008·Neurobiology of Learning and Memory·K D BakerN S Rickard
Jun 27, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A A HerroldT C Napier
Jan 18, 2012·Neurobiology of Disease·Matthew K BrittainNickolay Brustovetsky
Apr 12, 2011·Reviews in the Neurosciences·Ingie HongSukwoo Choi
Mar 8, 2007·Nature Reviews. Neuroscience·Natalie C Tronson, Jane R Taylor
Feb 26, 2020·Annual Review of Neuroscience·Josué HaubrichKarim Nader
Apr 16, 2019·Frontiers in Physiology·Anna A TiunovaKonstantin V Anokhin
Feb 6, 2018·Neurobiology of Learning and Memory·Alessandro PivaCristiano Chiamulera

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