PMID: 7544588Nov 1, 1994Paper

The role of growth factors in the suppression of active cell death in the prostate: an hypothesis

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
R S Guenette, M Tenniswood

Abstract

Regression of the rat ventral prostate occurs when the level of 5 alpha-dihydrotestosterone, the trophic hormone, drops below the threshold required to suppress apoptosis. The induction of apoptosis in the ventral prostate is accompanied by the increase in the steady-state level of a number of mRNAs coding for proteins that are involved in the latter stages of apoptosis and thus represent secondary thanatogens. These include proteases (cathepsins, plasminogen activators, and collagenase), clusterin, poly(ADP)ribose polymerase, tenascin, and several unidentified genes, as well as several RNases and the classical Ca2+,Mg(2+)-dependent endonuclease. In addition, insulin-like growth-factor-binding protein 5 (IGFBP-5) is induced de novo. We propose that IGFBP-5 may serve to trigger the apoptotic process through the attenuation of the insulin-like growth factor signalling system (which is necessary for cell survival), and as such, represents a primary thanatogen in the prostate.

Citations

Feb 3, 1998·American Journal of Respiratory Cell and Molecular Biology·L M ScavoJ A Kitterman
Dec 23, 2000·The Journal of Urology·R N CoffeyJ M Fitzpatrick
Mar 11, 2006·The Biochemical Journal·James BeattieDavid J Flint
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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis