The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

Frontiers in Endocrinology
Jesús Devesa, Diego Caicedo

Abstract

Although not yet well-understood, today it is clear that Growth Hormone (GH) exerts a relevant role in the regulation of ovulation and fertility; in fact, fertility is lower in women with GH deficiency (GHD), and GH receptors (GHR) and GH mRNA have been found in the ovary since the onset of follicular development in humans. However, despite the strong evidence of GH in the regulation of fertility, many aspects of GH actions at this level are still not well-established, and it is likely that some controversial data depend on the species analyzed, the dose of the hormone and the duration of use of GH. Folliculogenesis, ovulation, and corpus luteum formation and maintenance are processes that are critically dependent on angiogenesis. In the ovary, new blood vessel formation facilitates oxygen, nutrients, and hormone substrate delivery, and also secures transfer of different hormones to targeted cells. Some growth factors and hormones overlap their actions in order to control the angiogenic process for fertility. However, we still know very little about the factors that play a critical role in the vascular changes that occur during folliculogenesis or luteal regression. To promote and maintain the production of VEGF-A in granulosa ...Continue Reading

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Citations

Oct 19, 2019·International Journal of Molecular Sciences·Mariusz T SkowronskiAgnieszka Skowronska
Nov 30, 2019·Frontiers in Endocrinology·Emina IpsaKevin N Keane
May 16, 2020·F1000Research·Juni HandajaniWihaskoro Sosroseno
Nov 27, 2020·Cancers·Naomi BrookArun Dharmarajan
Apr 3, 2021·Therapeutic Advances in Reproductive Health·Robert J Norman, Roger J Hart
Nov 13, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Qiao-Li ChenHong Ye

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