PMID: 11927680Apr 3, 2002Paper

The role of guanylyl cyclases in the permeability response to inflammatory mediators in pial venular capillaries in the rat

The Journal of Physiology
M H Sarker, P A Fraser

Abstract

Inflammatory mediators have a role in the formation of cerebral oedema and there is evidence that cGMP is an important signal in vascular permeability increase. We have investigated the role and the source of cGMP in mediating the permeability response to acutely applied bradykinin and the histamine H(2) agonist dimaprit on single cerebral venular capillaries, by using the single vessel occlusion technique. We found that 8-bromo-cGMP applied acutely resulted in a small and reversible permeability increase with a log EC(50) -7.2 +/- 0.15 M. KT 5823, the inhibitor of cGMP-dependent protein kinase, abolished the permeability responses to both bradykinin and dimaprit, while zaprinast, an inhibitor of type 5 phosphodiesterase, potentiated the response to bradykinin. On the other hand, L-NMMA blocked the response to dimaprit, but not that to bradykinin. Inhibitors of soluble guanylyl cyclase, LY 85353 and methylene blue, also inhibited the permeability response to dimaprit, but not bradykinin. The permeability responses to the natriuretic peptides ANP and CNP were of similar magnitude to that of bradykinin with log EC(50) -10.0 +/- 0.33 M and -8.7 +/- 0.23 M, respectively. The natriuretic peptide receptor antagonist HS-142-1 blocked ...Continue Reading

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Citations

Jul 16, 2013·Progress in Neurobiology·Marijke De BockLuc Leybaert
May 16, 2003·Vascular Pharmacology·Sarah Y Yuan
Jan 23, 2004·Archives of Disease in Childhood·D B DungerUNKNOWN LWPES
Dec 14, 2011·Advanced Drug Delivery Reviews·Yan Chen, Lihong Liu
Mar 23, 2010·Neurochemistry International·Judith PradoAgustina García
Jan 9, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manoj BoharaAtsuro Miyata
Feb 10, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Mosharraf H SarkerPaul A Fraser
May 25, 2005·Peptides·Angelika M Vollmar
Oct 4, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Shinji FukuiAnthony Marmarou
Jul 31, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Kevin A Strauss, D Holmes Morton

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