PMID: 8950841Jan 1, 1996Paper

The role of gut inflammation in the pathogenesis of spondyloarthropathies

Acta Clinica Belgica
H MielantsE M Veys

Abstract

The concept of spondyloarthropathy (SpA) gathers together a group of chronic diseases with common clinical, biological, genetic and therapeutic characteristics. The concept forms a distinct entity, different from other rheumatic diseases. The target organs are not only the joint, but also the axial skeleton, the enthesis, the eye, the gut, urogenital tract, the skin and sometimes the heart. The prevalence of this entity in the general population is estimated 1%, equal to the prevalence of rheumatoid arthritis. Genetical predisposition (HLA-B27) is one of the clues to the pathogenesis of the disease. Since reactive arthritis is induced by specific urogenital or enterogenic bacteriae, and since the gut is implicated in different forms of spondyloarthropathies, especially in IBD, it was clear that the gut could play an important role by permitting exogenous factors to enter the body. This hypothesis was the rationale for investigating the gut in the spondyloarthropathies by performing ileocolonoscopies. In the first ileocolonoscopic studies of SpA patients, histological signs of gut inflammation were found in a relatively great number of patients, mostly without any clinical intestinal manifestations. These lesions were not seen i...Continue Reading

References

Jan 1, 1988·British Journal of Rheumatology·H MielantsM de Vos

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Citations

Mar 15, 2018·Current Opinion in Rheumatology·Rene Y ChoiJames T Rosenbaum
Apr 3, 2001·International Immunology·V S ChanH C Bodmer
Jun 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Maria de Los Angeles PinedaGregor Reid
Aug 18, 2016·Clinical Rheumatology·Ariel ZoharDevy Zisman
Jan 1, 2016·Rheumatology International·Jayakanthan KabeerdossDebashish Danda
Sep 21, 2001·Current Rheumatology Reports·Y LiuK Granfors
Feb 14, 2009·The Journal of International Medical Research·R E ToğrolB Sahan

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