The role of gut microbiota in programming the immune phenotype

Journal of Developmental Origins of Health and Disease
M Weng, W A Walker

Abstract

The human fetus lives in a germ-free intrauterine environment and enters the outside world containing microorganisms from several sources, resulting in gut colonization. Full-term, vaginally born infants are completely colonized with a diverse array of bacterial families in clusters (Phyla) and species (>1000) by the first year of life. Colonizing bacteria communicating with the gut epithelium and underlying lymphoid tissues ('bacterial-epithelial crosstalk') result in a functional immune phenotype and no expression of disease (immune homeostasis). Appropriate colonization is influenced by the prebiotic effect of breast milk oligosaccharides. Adequate colonization results in an innate and adaptive mucosal immune phenotype via communication between molecular patterns on colonizing bacteria and pattern-recognition receptors (e.g., toll-like receptors) on epithelial and lymphoid cells. This ontogeny affects the immune system's capacity to develop oral tolerance to innocuous bacteria and benign antigens. Inadequate intestinal colonization with premature delivery, delivery by Cesarean section and excessive use of perinatal antibiotics results in the absence of adequate bacterial-epithelial crosstalk and an increased incidence of imm...Continue Reading

References

Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·J J CebraJ Tseng
Oct 1, 1985·The Journal of Clinical Investigation·T GanzR I Lehrer
May 1, 1995·International Archives of Allergy and Immunology·I R Sanderson, W A Walker
Jan 1, 1994·Annual Review of Immunology·K E Mostov
Feb 5, 1999·European Journal of Immunology·M R KarlssonU I Dahlgren
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·N N NanthakumarW A Walker
Jun 8, 2001·The American Journal of Clinical Nutrition·B Deplancke, H R Gaskins
Mar 26, 2002·Nature Reviews. Immunology·Carl G FigdorGosse J Adema
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N Nanda NanthakumarW Allan Walker
Jun 7, 2003·Science·Stephen E GirardinDana J Philpott
Aug 5, 2003·The Journal of Allergy and Clinical Immunology·Merete EggesbøPer Magnus
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Erika C ClaudBobby J Cherayil
Sep 2, 2004·Nature Medicine·Warren Strober
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lauren S Collier-HyamsAndrew S Neish
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Meng-Tsung TienThierry Pédron
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sophie ChabotMarian R Neutra
Nov 23, 2006·Seminars in Immunology·Karen SmithAndrew J Macpherson
Dec 6, 2006·The Journal of Experimental Medicine·Marcello ChieppaRonald N Germain
Jun 28, 2007·PLoS Biology·Chana PalmerPatrick O Brown
Sep 14, 2007·Annual Review of Physiology·Christine L Hattrup, Sandra J Gendler
Sep 14, 2007·Annual Review of Physiology·David J ThorntonMichael A McGuckin
Feb 13, 2008·The Journal of Experimental Medicine·Siegfried HapfelmeierWolf-Dietrich Hardt
Mar 29, 2008·Veterinary Immunology and Immunopathology·Linda L Agnew, Ian G Colditz
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Francesca Granucci, Ivan Zanoni
May 30, 2008·Nature·Sarkis K MazmanianDennis L Kasper
Jun 14, 2008·Immunity·Andrea Cerutti, Maria Rescigno
Sep 19, 2008·Immunity·Yasmine Belkaid, Guillaume Oldenhove

❮ Previous
Next ❯

Citations

Apr 26, 2014·Nutrients·Elvira VerduciMarcello Giovannini
Oct 22, 2014·Microbiome·Maureen W GroerJack A Gilbert
Oct 27, 2015·Biomolecules·Sheena PatelAli Keshavarzian
Feb 9, 2016·Scientific Reports·Michael J McGeachieAugusto Litonjua
Dec 15, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Maureen W GroerW Allan Walker
Jan 9, 2016·Gut Microbes·Randi LundbergCamilla H F Hansen
Apr 17, 2016·The Journal of Surgical Research·Jason Fawley, David M Gourlay
Oct 30, 2015·Early Human Development·Giovanni AlmanzarMartina Prelog
Feb 11, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vito Leonardo MinielloRuggiero Francavilla
Jul 16, 2015·Gut Microbes·Nicole R NarayanDennis J Hartigan-O'Connor
Sep 2, 2015·ILAR Journal·Axel Kornerup HansenCamilla Hartmann Friis Hansen
Oct 7, 2015·Frontiers in Immunology·Lea-Maxie Haag, Britta Siegmund
Aug 1, 2015·Future Microbiology·Leonard A Mermel
May 13, 2015·Nature Reviews. Nephrology·Jonathan S BrombergEmmanuel F Mongodin
Dec 3, 2015·Current Obesity Reports·Jessica G Woo, Lisa J Martin
May 14, 2016·Nutrition Research Reviews·Eugeni RouraDavid Val-Laillet
Jun 29, 2016·European Archives of Psychiatry and Clinical Neuroscience·G FondUNKNOWN FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) Group
Mar 18, 2016·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Marilyn Urrutia-PereiraDirceu Solé
Jan 10, 2018·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·D Rose Ewald, Susan C J Sumner
Jun 19, 2017·Journal of Applied Genetics·Axel Kornerup HansenStine B Metzdorff
Nov 22, 2017·Korean journal of pediatrics·Yong-Sung Choi, In Gyu Song
Oct 14, 2014·Pediatric Research·W Allan Walker, Rajashri Shuba Iyengar
Jun 1, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jacob K OlsonGail E Besner
Jul 19, 2018·Medical Sciences : Open Access Journal·Majda DzidicMaria Carmen Collado
Jul 29, 2017·The Journal of Endocrinology·Christopher M Mulligan, Jacob E Friedman
Sep 6, 2018·QJM : Monthly Journal of the Association of Physicians·S ChuJ Zhang
Sep 5, 2014·Science Translational Medicine·Amir ArdeshirDennis J Hartigan-O'Connor
Nov 16, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuko ShigenoKentaro Nagaoka
Apr 11, 2018·Nature Medicine·Jack A GilbertRob Knight
Jun 6, 2014·Expert Review of Clinical Immunology·Misty GoodDavid J Hackam
Feb 11, 2015·Journal of Medical Microbiology·Behrooz Mozaffari naminMohammad Mehdi Soltan Dallal
Nov 6, 2018·Current Pediatric Reviews·Catalina Bazacliu, Josef Neu
Sep 19, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Lisanne M G VerschurenMario P L Calus
Jan 30, 2020·Nutrients·Ignasi Azagra-BoronatMaria J Rodríguez-Lagunas
Mar 21, 2017·Journal of Immunology Research·Monika Adamczyk-SowaPawel Dobrakowski
Oct 29, 2014·The Cochrane Database of Systematic Reviews·Fiona M Smaill, Rosalie M Grivell
Dec 4, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Katerina KaraivazoglouChristos Triantos
Jul 21, 2020·World Journal of Gastroenterology : WJG·Elodie SarronPauline M Anton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
W A Walker
Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
Hai Ning Shi, Allan Walker
The British Journal of Nutrition
Maria Luisa Forchielli, W A Walker
© 2021 Meta ULC. All rights reserved