PMID: 33223Jan 1, 1979Paper

The role of H-2 and Ia antigens in graft-versus-host reactions (GVHR). Presence of host alloantigens on donor cells after GVHR and suppression of GVHR with an anti-Ia antiserum against hose Ia antigens

The Journal of Experimental Medicine
G J Prud'hommeT L Delovitch

Abstract

By using an indirect immunofluorescence technique, the presence of host cell derived H-2K, H-2D, and Ia alloantigens on donor cells recovered from recipient spleens after a graft-versus-host response (GVHR) was demonstrated. Mapping studies indicated that only host K, D, and I-A region gene products could be identified on the donor cells. Host I-E/C- and I-J-subregion products were not absorbed by donor cells. Treatment of activated donor cells with anti-Ly sera plus C' revealed that donor cells carrying host Ia antigens have a Ly-1+,2-,3- phenotype, whereas donor cells carrying H-2K and H-2D host antigens have a Ly-1-,2+,3+ phenotype. A GVHR that resulted from only an I-region incompatibility was suppressed by the injection of recipient mice with an anti-Ia antiserum directed against self Ia antigens. The degree of suppression was proportional to the amount of anti-Ia antiserum administered.

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Citations

Aug 1, 1982·The Journal of Experimental Medicine·L L Perry, M I Greene
Mar 1, 1983·The Journal of Experimental Medicine·G M Shearer, R B Levy
May 1, 1986·The Journal of Clinical Investigation·D Guy-Grand, P Vassalli
Jan 1, 1980·Scandinavian Journal of Immunology·B GänsbacherE D Albert
Apr 1, 1984·Immunological Reviews·G J Prud'hommeA N Theofilopoulos
Jul 1, 1984·The American Journal of Anatomy·J Clancy
Jan 1, 1991·Autoimmunity·G J Prud'hommeL E Vanier
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·H Bril, R Benner
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas J LangCharles S Via
Jul 1, 1980·The Journal of Investigative Dermatology·G Rowden

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