PMID: 6159447Nov 1, 1980Paper

The role of H-2-linked genes in helper T cell function. VII. Expression of I region and immune response genes by B cells in bystander help assays

The Journal of Experimental Medicine
P Marrack, J W Kappler

Abstract

The mode of action by bystander helper T cells was investigated by priming (responder X nonresponder) (B6A)F1 T cells with poly-L-(Tyr, Glu)-poly-D,L-Ala--poly-L-Lys [(TG)-A--L] and titrating the ability of these cells to stimulate an anti-sheep red blood cell (SRBC) response of parental B cells and macrophages in the presence of (TG)-A--L. Under limiting T cell conditions, and in the presence of (TG)-A--L, (TG)-A--L-responsive T cells were able to drive anti-SRBC responses of high-responder C57BL/10.SgSn (B10) B cells and macrophages (M0), but not of low-responder (B10.A) B cells and M0. Surprisingly, the (TG)-A--L-driven anti-SRBC response of B10.A B cells was not restored by addition of high-responder acessory cells, in the form of (B6A)F1 peritoneal or irradiated T cell-depleted spleen cells, or in the form of B10 nonirradiated T cell-depleted spleen cells. These results suggested that (TG)-A--L-specific Ir genes expressed by B cells controlled the ability of these cells to be induced to respond to SRBC by (TG)-A--L-responding T cells, implying that direct contact between the SRBC-binding B cell precursor and the (TG)-A--L-responsive helper T cells was required. Analogous results were obtained for keyhold limpet hemocyanin ...Continue Reading

References

Jun 1, 1979·The Journal of Experimental Medicine·S GillisK A Smith
Aug 1, 1974·Journal of Immunological Methods·I A Ly, R I Mishell
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton
Mar 1, 1980·The Journal of Experimental Medicine·A A Augustin, A Coutinho
Jan 1, 1980·The Journal of Experimental Medicine·M H SchreierF Melchers
Oct 1, 1980·The Journal of Experimental Medicine·L HarwellJ Kappler

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Citations

Jan 1, 1985·Immunogenetics·R J Hancock, D W Dresser
Jan 1, 1986·Springer Seminars in Immunopathology·R H ZublerP A Miescher
Mar 1, 1988·Annales De L'Institut Pasteur. Immunology·G Parisi
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V M SandersE S Vitetta
Nov 1, 1981·The Journal of Experimental Medicine·J L GreensteinP C Marrack
Jul 1, 1982·The Journal of Experimental Medicine·N W RoehmJ W Kappler
Mar 1, 1984·The Journal of Experimental Medicine·A L DeFrancoW E Paul
Sep 1, 1984·The Journal of Experimental Medicine·N W RoehmJ C Cambier
Jan 1, 1983·Developmental and Comparative Immunology·J Reimann, R G Miller
Mar 1, 1984·European Journal of Immunology·M J Ratcliffe, M H Julius
Oct 1, 1987·Immunological Reviews·E S VitettaT L Stevens
Jun 1, 1982·European Journal of Immunology·A LanzavecchiaF Celada
Aug 1, 1982·European Journal of Immunology·M H JuliusC L Sidman
Apr 1, 1984·Immunological Reviews·M HowardW E Paul
Apr 19, 2020·Immunological Reviews·Zhaolin Hua, Baidong Hou
Oct 1, 1984·American Journal of Reproductive Immunology : AJRI·C Hiramine, K Hojo

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