The Role of Hedgehog Signaling in Tumor Induced Bone Disease

Cancers
Shellese A Cannonier, Julie A Sterling

Abstract

Despite significant progress in cancer treatments, tumor induced bone disease continues to cause significant morbidities. While tumors show distinct mutations and clinical characteristics, they behave similarly once they establish in bone. Tumors can metastasize to bone from distant sites (breast, prostate, lung), directly invade into bone (head and neck) or originate from the bone (melanoma, chondrosarcoma) where they cause pain, fractures, hypercalcemia, and ultimately, poor prognoses and outcomes. Tumors in bone secrete factors (interleukins and parathyroid hormone-related protein) that induce RANKL expression from osteoblasts, causing an increase in osteoclast mediated bone resorption. While the mechanisms involved varies slightly between tumor types, many tumors display an increase in Hedgehog signaling components that lead to increased tumor growth, therapy failure, and metastasis. The work of multiple laboratories has detailed Hh signaling in several tumor types and revealed that tumor establishment in bone can be controlled by both canonical and non-canonical Hh signaling in a cell type specific manner. This review will explore the role of Hh signaling in the modulation of tumor induced bone disease, and will shed insig...Continue Reading

References

Feb 1, 1992·Endocrine Reviews·T SudaT J Martin
Mar 1, 1987·Medicine·R J Gorlin
Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
Feb 1, 1995·Journal of Pediatric Hematology/oncology·A ZvulunovN B Esterly
Nov 15, 1997·Cancer·G R Mundy
Aug 27, 1999·Biochemical and Biophysical Research Communications·H ItoT Nakamura
Sep 1, 2000·Science·S L Teitelbaum
Dec 7, 2000·Cancer Genetics and Cytogenetics·X Mao, R A Hamoudi
Feb 13, 2001·The Journal of Clinical Investigation·U I ChungH M Kronenberg
May 12, 2001·The Journal of Investigative Dermatology·J M BonifasE H Epstein
May 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·A B HuiH K Ng
Jun 18, 2002·Nature Genetics·Michael D TaylorDavid Hogg
Aug 31, 2002·Science·David M BermanPhilip A Beachy
Oct 3, 2002·Clinical Orthopaedics and Related Research·Dhruv B PatederRandy N Rosier
Nov 5, 2002·Genes & Development·James K ChenPhilip A Beachy
Jan 28, 2003·Cancer·Sanna-Maria Käkönen, Gregory R Mundy
Mar 22, 2003·Histochemistry and Cell Biology·T MiyajiH Yoshikawa
Apr 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Juliet A WilliamsFrank Y Wang
May 16, 2003·Nature·Henry M Kronenberg
Oct 2, 2003·Nature·Sarah P ThayerMatthias Hebrok
Dec 25, 2003·The Journal of Pathology·S RomeoP C W Hogendoorn
May 11, 2004·Endocrinology·Lian FanWade Bushman
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Pilar SanchezAriel Ruiz i Altaba
Sep 14, 2004·Nature·Sunil S KarhadkarPhilip A Beachy
Oct 16, 2004·Molecular Cancer·Tao ShengJingwu Xie
Jan 20, 2005·The British Journal of Dermatology·J ReifenbergerG Reifenberger
Jan 10, 2006·The American Journal of Pathology·Tri Dung TietJay S Wunder
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Natalia A RiobóCharles P Emerson

❮ Previous
Next ❯

Citations

Mar 7, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Johannes M WagnerBjörn Behr
Dec 29, 2016·Endocrinology and Metabolism·Hyo Min JeongSerk In Park
Aug 21, 2019·International Journal of Molecular Sciences·Wen-Ting LvChun-Jie Wang
Nov 22, 2017·Archives of Pharmacal Research·Guanghai JinKyeong Lee
Sep 9, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joseph P VanderburghJulie A Rhoades
May 9, 2021·Biochemical Pharmacology·Su-Fen WeiYong-Qiang Liu
Aug 24, 2021·Carbohydrate Polymers·Zhujie XuLipeng Qiu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of Oncology : Official Journal of the European Society for Medical Oncology
R GraffeoA Goldhirsch
Nihon rinsho. Japanese journal of clinical medicine
Nobuyuki UdagawaNaoyuki Takahashi
© 2021 Meta ULC. All rights reserved