The role of heme iron molecules derived from red and processed meat in the pathogenesis of colorectal carcinoma

Critical Reviews in Oncology/hematology
S M K GamageVinod Gopalan

Abstract

Emerging evidence that heme iron in red meat is a risk factor for colorectal carcinogenesis is a topic that has received recent scrutiny. This review aims to summarise the mechanism of colorectal carcinogenesis by heme contained in red and processed meat. Heme iron can induce cytotoxicity by 'cytotoxic heme factor' and promote surface epithelial cell apoptosis and compensatory epithelial hyperplasia. Heme, induces peroxidation of lipids, leading to free radical formation and generation of DNA adducts in colorectal epithelial cells. In addition, heme catalyses the formation of N-nitroso-compounds, which in turn results in the initiation of colorectal carcinogenesis. Emerging data suggest that intestinal dysbiosis can promote carcinogenic properties of heme. Heme induces multiple genetic alterations by regulating WNT signalling pathway and causing mutations in major colon cancer genes such as APC, TP53 and KRAS. However, a balanced diet containing green vegetables, olive oil and calcium may reduce the carcinogenic effects of heme.

Citations

Nov 10, 2018·Cell & Bioscience·Sarada Preeta KalainayakanLi Zhang
Dec 12, 2018·Frontiers in Oncology·Christa Pfeifhofer-ObermairManfred Nairz
Jan 27, 2019·International Journal of Molecular Sciences·Rossella CianciGiovanni Cammarota
Oct 30, 2018·Journal of Cancer Prevention·Kichul Yoon, Nayoung Kim
Feb 6, 2020·Frontiers in Oncology·Veronica FioritoEmanuela Tolosano
Aug 21, 2020·International Journal of Epidemiology·Anika KnuppelAurora Perez-Cornago
Jul 28, 2020·Oxidative Medicine and Cellular Longevity·Alda Pereira da SilvaManuel Bicho
Aug 29, 2019·Nature Reviews. Gastroenterology & Hepatology·NaNa Keum, Edward Giovannucci
Aug 6, 2020·International Journal of Molecular Sciences·Naoko KandaHidehisa Saeki
Dec 10, 2020·Transfusion·Ralph R Vassallo
Feb 24, 2021·Public Health Nutrition·Kai-Yan LiuCai-Xia Zhang
Apr 17, 2021·Scientific Reports·Alexandr B DuzhakYuri P Tsentalovich
Apr 28, 2021·Experimental and Molecular Pathology·Sujani M K GamageVinod Gopalan
Jul 10, 2021·Pathology, Research and Practice·Sujani Madhurika Kodagoda GamageVinod Gopalan
Jul 23, 2021·The Journal of Dermatological Treatment·Kawina IngkapairojSumanas Bunyaratavej
Aug 4, 2021·PloS One·Gambhir ShresthaPranil Man Singh Pradhan
Aug 10, 2021·Human Pathology·Sujani M Kodagoda GamageAlfred K Lam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
Khawla S Al-Kuraya
IARC Scientific Publications
V MorenoBellvitge Colorectal Cancer Study Group
Journal of Epidemiology and Community Health
R N Maric, K K Cheng
© 2022 Meta ULC. All rights reserved