The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice

Journal of Atherosclerosis and Thrombosis
Kiyoe KurahashiKen-ichi Aihara

Abstract

Accelerated thrombin action is associated with insulin resistance. It is known that upon activation by binding to dermatan sulfate proteoglycans, heparin cofactor Ⅱ(HCⅡ) inactivates thrombin in tissues. Because HCⅡ may be involved in glucose metabolism, we investigated the relationship between plasma HCⅡ activity and insulin resistance. In a clinical study, statistical analysis was performed to examine the relationships between plasma HCⅡ activity, glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), and homeostasis model assessment-insulin resistance (HOMA-IR) in elderly Japanese individuals with lifestyle-related diseases. Multiple regression analysis showed significant inverse relationships between plasma HCⅡ activity and HbA1c (p=0.014), FPG (p=0.007), and HOMA-IR (p= 0.041) in elderly Japanese subjects. In an animal study, HCⅡ+/+ mice and HCⅡ+/- mice were fed with a normal diet or high-fat diet (HFD) until 25 weeks of age. HFD-fed HCⅡ+/- mice exhibited larger adipocyte size, higher FPG level, hyperinsulinemia, compared to HFD-fed HCⅡ+/+ mice. In addition, HFD-fed HCⅡ+/- mice exhibited augmented expression of monocyte chemoattractant protein-1 and tumor necrosis factor, and impaired phosphorylation of the serine/t...Continue Reading

References

Apr 13, 1999·Cell·S I Taylor
Dec 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·W M CheungB P Damiano
Apr 11, 2006·Nature Medicine·Matthew J WattGregory R Steinberg
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Aug 24, 2006·American Journal of Physiology. Endocrinology and Metabolism·Carey N LumengAlan R Saltiel
Nov 4, 2006·The Journal of Biological Chemistry·Tamon SakaiMasato Kasuga
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Mar 21, 2007·Biochemical Society Transactions·B Dummler, B A Hemmings
Jun 6, 2007·The Journal of Clinical Investigation·Ken-ichi AiharaToshio Matsumoto
Oct 18, 2007·Journal of Animal Science·M LorenzoI Nieto-Vazquez
Jul 17, 2008·Archives of Physiology and Biochemistry·Iria Nieto-VazquezMargarita Lorenzo
Mar 10, 2009·Journal of Inflammation·Jennifer L Strande, Shane A Phillips
Jul 2, 2010·The Journal of Biological Chemistry·Praveen PapareddyArtur Schmidtchen
Sep 10, 2010·Journal of Biosciences·Nirmala Yabaluri, Murali D Bashyam
Nov 26, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takayuki IseToshio Matsumoto
Aug 4, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Caroline SanchezMarie-Christine Alessi
May 10, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martina KalleArtur Schmidtchen
Jun 29, 2013·Diabetes & Metabolism Journal·Tsuguhito Ota
Aug 22, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Junxian LimDavid P Fairlie
Oct 5, 2013·Blood·Fahumiya Samad, Wolfram Ruf
Mar 11, 2016·World Journal of Diabetes·Vemana GowdNandini D Chilkunda
Dec 13, 2016·The Biochemical Journal·Philip NewsholmePaulo Ivo Homem de Bittencourt

❮ Previous
Next ❯

Citations

Aug 11, 2017·Journal of Atherosclerosis and Thrombosis·Yutaka Hasegawa, Yasushi Ishigaki
Mar 7, 2021·Scientific Reports·Abu Saleh Md MoinStephen L Atkin
Jul 13, 2021·Frontiers in Endocrinology·Abu Saleh Md MoinAlexandra E Butler
Jul 3, 2021·Molecular & Cellular Proteomics : MCP·Xiaoyan LiuWei Sun

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

PCR Array System
ImageJ

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.