The role of hepatic, renal and intestinal gluconeogenic enzymes in glucose homeostasis of juvenile rainbow trout

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
S KirchnerRonaldo P Ferraris

Abstract

Rainbow trout is unable to utilize high levels of dietary carbohydrates and experiences hyperglycemia after consumption of carbohydrate-rich meals. Carbohydrates stimulate hepatic glycolytic activity, but gene expression of the rate-limiting gluconeogenic enzymes glucose-6-phosphatase (G6Pase), fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase (PEPCK) remains high. Although there is significant mRNA expression and activity of gluconeogenic enzymes in trout intestine and kidney, the regulation of these enzymes by diet is not known. We tested the hypothesis that dietary carbohydrate modulates intestinal and renal G6Pase, FBPase and PEPCK. Fish were either fasted or fed isocaloric carbohydrate-free (CF) or high carbohydrate (HC) diets for 14 days. As expected, fish fed HC exhibited postprandial hyperglycemia and enhanced levels of hepatic glucokinase mRNA and activity. Dietary carbohydrates had no significant effect on the expression and activity of PEPCK, FBPase and G6Pase in all three organs. In contrast, fasting enhanced the activity, but not the mRNA expression of both hepatic and intestinal PEPCK, as well as intestinal FBPase. Therefore, the activity of rate-limiting gluconeogenic enzymes in trout can...Continue Reading

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Citations

Apr 6, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Sergio PolakofThomas W Moon
Jul 16, 2013·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sergio Polakof, José L Soengas
Jun 5, 2014·Nutrition Research Reviews·Stéphane PanseratSergio Polakof
Dec 15, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Biju Sam KamalamFrançoise Médale
Aug 30, 2011·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sergio PolakofJosé L Soengas
Jul 19, 2015·Molecular and Cellular Endocrinology·Vanessa ScheinRoselis S M da Silva
Jul 23, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ivan ViegasJohn G Jones
May 4, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Cristina Otero-RodiñoJosé L Soengas
May 30, 2017·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·João RitoJohn G Jones
Jan 3, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marina SubramaniamMatthew E Loewen
Jun 26, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S PanseratT W Moon
Apr 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sergio PolakofJosé L Soengas
Jul 10, 2019·Physiological Genomics·Daniel J KostyniukJan A Mennigen
Nov 21, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marina SubramaniamMatthew E Loewen
Jan 24, 2017·Frontiers in Neuroscience·Marta Conde-Sieira, José L Soengas
Aug 27, 2019·Marine Environmental Research·Angela Carolina GuillenLucélia Donatti
Feb 11, 2021·International Journal of Environmental Research and Public Health·Maurizio Manera
Jul 13, 2012·The Journal of Experimental Biology·Biju Sam KamalamStephane Panserat

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