The role of high-density lipoproteins in the regulation of angiogenesis

Cardiovascular Research
Joanne T M TanChristina A Bursill

Abstract

Angiogenesis is important for postnatal physiological processes including tissue neovascularization in response to an ischaemic injury. Conversely, uncontrolled inflammatory-driven angiogenesis can accelerate atherosclerotic plaque and tumour growth. Angiogenesis-associated diseases are highly prevalent globally, with cardiovascular-related disorders and cancer being the leading causes of mortality worldwide. A vast amount of research has been conducted on the vasculoprotective effects of high-density lipoproteins (HDLs) and while current HDL-raising therapies to date have not yielded the desired benefits clinically, its role in angiogenesis is yet to be fully elucidated. Epidemiological studies report positive correlations between elevated HDL levels and improved prognosis in both ischaemia- and inflammatory-driven pathologies, in which angiogenesis plays a key role. This review focuses on current evidence from epidemiological and prospective studies, coupled with animal models and mechanistic studies that highlight the ability of HDL to conditionally regulate angiogenesis.

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Citations

Oct 13, 2017·Science Translational Medicine·Sarah E HeywoodBronwyn A Kingwell
Jul 1, 2018·International Journal of Molecular Sciences·Nathan K P WongJoanne T M Tan
Apr 1, 2016·Current Opinion in Lipidology·Arnold von Eckardstein, Lucia Rohrer
Jun 8, 2018·International Journal of Molecular Sciences·Nathan K P WongChristina A Bursill
Feb 27, 2021·Journal of the American Heart Association·Seonhwa LeeSang-Hak Lee
Apr 4, 2021·International Journal of Molecular Sciences·Stanislav Kotlyarov
May 22, 2021·Journal of Cellular Physiology·Tan-Jun ZhaoLi Qin

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