The role of histamine in wound healing. II. The effect of antagonists and agonists of histamine receptors (H1 and H2) on collagen levels in granulation tissue

Agents and Actions
R Dabrowski, C Maśliński

Abstract

The effects of mepyramine (H1-receptor antagonist), cimetidine (H2-receptor antagonist), IEM-813 (H1-receptor agonist) abd 4-Met-Hi (H2-receptor agonist) on collagenogenesis processes in subcutaneous implanted sponges of rats were studied. Administration into sponges of cimetidine 30 min before histamine injection blocked both the stimulatory effect of low histamine doses and the inhibitory effect of high histamine doses of collagen formation. Low doses of 4-Met-Hi increased collagen levels but reduced the levels at high doses. Mepyramine and IEM-813 did not influence collagen biosynthesis.

References

May 1, 1967·Analytical Biochemistry·K I KivirikkoD J Prockop

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Citations

Mar 1, 1996·Amino Acids·S DinçerS L Dinçer
Apr 1, 1984·Agents and Actions·R Dabrowski, A Szczepanowska
Oct 1, 1986·Agents and Actions·D M GoldmanA U Demetriou
Mar 1, 1994·Biulleten' eksperimental'noĭ biologii i meditsiny·A V Denisov
Nov 1, 1993·The Journal of Hand Surgery·J S GebhardR A Meals
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Felipe V RodriguesLydia M Ferreira
Sep 7, 2014·Clinical and Experimental Nephrology·Keyue LiuMasahiro Nishibori
Sep 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karsten WellerMarcus Maurer

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