The role of histone lysine methyltransferase NSD3 in cancer

OncoTargets and Therapy
Xu HanXiaozhou He

Abstract

The growing number of findings demonstrate that nuclear receptor suppressor of variegation, enhancer of zeste, and trithorax domain-containing 3 (NSD3) is amplified and overexpressed in multiple cancer types. Nevertheless, the biological roles of NSD3 in carcinogenesis have not been well understood. In this review, we summarize the current knowledge on the mechanisms underlying NSD3 regulation in different cancers. In addition, NSD3 may serve as a potential druggable target for selective cancer therapy in the future.

Citations

May 31, 2019·Cellular and Molecular Life Sciences : CMLS·Jie LiGang Greg Wang
Jan 1, 2020·IUBMB Life·Javid Sadri NahandHamed Mirzaei
Jun 21, 2019·Journal of Cellular and Molecular Medicine·Xin Shi, Mingfu Fan

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Methods Mentioned

BETA
RNA-seq

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