The role of histone modifications and variants in regulating gene expression in breast cancer.

Journal of Mammary Gland Biology and Neoplasia
Mathieu Dalvai, K Bystricky

Abstract

The role of epigenetic phenomena in cancer biology is increasingly being recognized. Here we focus on the mechanisms and enzymes involved in regulating histone methylation and acetylation, and the modulation of histone variant expression and deposition. Implications of these epigenetic marks for tumor development, progression and invasiveness are discussed with a particular emphasis on breast cancer progression.

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Citations

Jul 12, 2013·Oxidative Medicine and Cellular Longevity·Alexandra Muñoz, Max Costa
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