PMID: 91304Aug 1, 1979Paper

The role of HLA-B27 in the diagnosis of low back pain

Acta Orthopaedica Scandinavica
I Jajić

Abstract

The HLA-B27 antigen was determined in 652 patients with low back pain which had lasted for more than 3 months. A clinical and roentgenological examination of the sacroiliac joints and the thoraco-lumbar spine was performed in all the patients. The control group consisted of 302 unrelated persons who did not show signs of low back pain. Antigen HLA-B27 was found in 276 of these 652 patients attending the ward for rheumatic diseases (42.4 per cent) and in 37 of the 302 unrelated persons in the control group (12.2 per cent). The difference is statistically highly significant (P less than 0.001). Ankylosing spondylitis was found in 128 out of the 276 patients with low back pain and antigen HLA-B27. This demonstrates the importance of this antigen in the differential diagnosis of low back pain.

References

Feb 1, 1975·Seminars in Arthritis and Rheumatism·D A Brewerton, D C James
Jan 1, 1974·Tissue Antigens·A KastelanP Maćasović
Dec 5, 1964·Nature·P I TERASAKI, J D MCCLELLAND
Jan 1, 1965·Postgraduate Medical Journal·J R ARMSTRONG, E J SHEARER

❮ Previous
Next ❯

Citations

Jun 25, 2010·International Journal of Immunogenetics·O M PopaL Popa
Jan 1, 1988·International Orthopaedics·A O ShannakS T Hadidi
Aug 11, 2020·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Mallory PerryAngela Starkweather
Dec 1, 1987·Baillière's Clinical Rheumatology·P Helliwell, V Wright

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.