The role of HOTAIR-induced downregulation of microRNA-126 and interleukin-13 in the development of bronchial hyperresponsiveness in neonates

Journal of Cellular Physiology
Dong-Mei WuJun Lu

Abstract

Long noncoding RNAs, including HOTAIR, are involved in the pathogenesis of a wide range of diseases. This study aimed to explore the mechanism underlying the involvement of HOTAIR in neonatal bronchial hyperresponsiveness (BHR). A total of 105 newborns were recruited in this study to collect their peripheral blood mononuclear cell and serum samples, which were then divided into different genotype groups based on the genotypes of rs4759314, rs874945, and rs7958904. The real-time polymerase chain reaction, western blot analysis, computational analyses, and luciferase assays were performed to establish the regulatory relationships between the HOTAIR, microRNA-126 (miR-126), and interleukin-13 (IL-13). The level of HOTAIR, miR-126, and IL-13 among rs4759314 AA, AG, and GG groups, as well as among rs874945 GG, AG, and AA groups was similar. However, the level of HOTAIR was increased in the rs7958904 GG group, accompanied by a decreased level of miR-126 and IL-13. In addition, the level of airway responsiveness was comparable among rs4759314 AA, AG, and GG groups, as well as among rs874945 GG, AG, and AA groups. However, the airway responsiveness in the groups rs7958904 CG and CC was much stronger than that of the GG group. We also d...Continue Reading

References

Aug 1, 1992·The American Review of Respiratory Disease·H NakajimaS Yoshida
Sep 1, 1990·The American Review of Respiratory Disease·P K PattemoreA W Stewart
Apr 1, 1995·The Journal of Experimental Medicine·P R BurdF C Mills
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Jan 4, 2001·The New England Journal of Medicine·A B Kay
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D M WalterD T Umetsu
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Jie-Pan Shen, Calvin U Cotton
Dec 12, 2002·Current Opinion in Pulmonary Medicine·Marsha Wills-Karp, Monica Chiaramonte
Dec 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C E BrightlingP Bradding
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Harold S Nelson
Apr 1, 2006·Cytogenetic and Genome Research·A GaboryL Dandolo
Oct 3, 2006·Developmental Cell·Wigard P Kloosterman, Ronald H A Plasterk
Aug 12, 2008·Current Molecular Medicine·Douglas A Kuperman, Robert P Schleimer
May 20, 2009·Journal of Leukocyte Biology·Kelly M KroegerRichard M Locksley
Jul 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deepti R NagarkarMarc B Hershenson
Oct 12, 2010·RNA Biology·Tiffany Hung, Howard Y Chang
Jun 1, 2011·Human Genetics·Daphne B Pontier, Joost Gribnau
Aug 5, 2011·The New England Journal of Medicine·Jonathan CorrenJohn G Matthews
Jun 19, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carla OseroffAlessandro Sette
Oct 26, 2012·Current Opinion in Pulmonary Medicine·Catherine M Greene, Kevin P Gaughan
Jan 17, 2014·Nature·Yvonne TayPier Paolo Pandolfi
Dec 3, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jin YanGuoxin Zhang

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